The aims of this study were to investigate human papillomavirus (HPV) genotypes in women with cervical intraepithelial lesions and cervical cancer (CC) in Honduras and to identify epidemiological cofactors that contribute to the development of CC.
Among the 289 patients analyzed, 139 had low-grade squamous intraepithelial lesion (LSIL), 60 had high-grade squamous intraepithelial lesion (HSIL), and 90 had CC.
The HPV DNA was detected in 113 women (81%) with LSIL, in 58 women (97%) with HSIL, and in 84 women (93%) with CC. Twenty-five HPV genotypes were found. Human papillomavirus type 16 was detected in 41% of women with CC, in 35% of women with HSIL, and in 24% of women with LSIL. Human papillomavirus type 18 was found in 9% of women with CC, in 4% of women with HSIL, and 5% of women with LSIL.
Therefore, implementation of the prophylactic vaccines against HPV genotypes 16 and 18 has the potential of preventing at least a quarter of LSIL, one third of HSIL, and about half of CC cases in Honduras.
HPV genotypes 16 and 18 are responsible of a quarter of LSIL, one third of HSIL and half of CC cases in Honduras.
1School of Microbiology, Science Faculty, Universidad Nacional Autónoma de Honduras; 2Department of Oncology and Gynaecology, Hospital General San Felipe, Tegucigalpa, Honduras; 3Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen; 4DDL Diagnostic Laboratory, Voorburg; and 5Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
Reprint requests to: Annabelle Ferrera, PhD, Department of Microbiology, Universidad Nacional Autónoma de Honduras, PO Box 30078, Tegucigalpa, Honduras. E-mail: email@example.com; firstname.lastname@example.org
This study was supported by The Netherlands Foundation for the Advancement of Tropical Research (WOTRO no. WB 92-215).