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Molluscum Contagiosum: Therapeutic Response to Trichloroacetic Acid in Pregnant Patients

Audisio, Teresita M. MD1; Pelliza Palmes, Maria Nuria MD1; Ringelheim, Claudia MD1; Rodríguez González, Oscar MD1; Crespo Roca, Francisco MD1; Ruperez, Casilda BSc2

Journal of Lower Genital Tract Disease: October 2009 - Volume 13 - Issue 4 - p 252-255
doi: 10.1097/LGT.0b013e31819b224e
Original Articles

Objective: This study aimed to evaluate the clinical response of pregnant patients affected by Molluscum contagiosum (MC) to treatment with a 90% solution of trichloroacetic acid (TCA). It also aimed to study the diagnostic frequency of MC in adult women coming for consultation to a Lower Genital Tract Office hospital-based outpatient clinic in the city of Cordoba (Argentina) and, second, to study the response of the MC to treatment with Imiquimod cream in some cases.

Materials and Methods: A retrospective case-series analysis of 30 patients presenting with MC. The data collected included the prevalence of MC in pregnant versus nonpregnant women, patient age, frequency age, lesion location, and associated pathologies.

Results: The prevalence levels of MC in pregnant and nonpregnant women were 1.2% and 0.8%, respectively. The greatest frequency was found in the 16- to 20-year age group. No patient was HIV+. Lesion location was 54.5% in the genitocrural fold, with the rest in the perianal region and in different areas of the external genitalia. The patients were treated during a minimum period of 1 week to a maximum period of 4 weeks. A 90% solution of TCA treatment showed full response after a single application, 17 (94%) of the 18 showed full response, averaging 1.06 weeks of treatment. Three nonpregnant patients were treated with a 5% solution of imiquimod, 66.6% showing full response by the fourth week of treatment.

Conclusions: We observed MC in the genital area of young pregnant patients relatively frequently (3%), associating its presence with diminished immune response. A 90% solution of TCA is highly effective with 1 application, the subsequent pain and burning sensation being immediately reduced by the application of aluminum hydroxide.

Trichloroacetic acid appears to be an efficient treatment option (giving good results in a short time at low cost) for genital molluscum contagiosum in pregnant patients. This is a relevant fact because of the safety of the procedure and the greater prevalence of the disease among pregnant women.

1Department of Obstetrics and Gynecology, Maternal and Newborn Hospital, Cordoba, Argentina; and 2Department of Probability and Statistics, School of Astronomy, Mathematics and Physics, Cordoba National University, Cordoba, Argentina

Reprint requests to: Teresita M. Audisio, MD, La Rioja 993, Cordoba 5000, Argentina. E-mail:

©2009The American Society for Colposcopy and Cervical Pathology