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Aggressive Angiomyxoma of the Vulva: A Case Report and Review of the Literature

Sereda, Danya MD; Sauthier, Philippe MD; Hadjeres, Rachid MD; Funaro, Deana MD

Journal of Lower Genital Tract Disease: January 2009 - Volume 13 - Issue 1 - p 46-50
doi: 10.1097/LGT.0b013e318180436f
Case Report

Background. Aggressive angiomyxoma is a variant of myxoid neoplasms of the female pelvic soft parts. The term "aggressive" refers to the tumor's locally infiltrative and recurrent nature because distant metastases are rare.

Case. A 25-year-old woman presented with a 9-month history of an asymptomatic, polypoid mass arising from the right anterior labium minus. Histopathological and radiological examinations were consistent with a diagnosis of aggressive angiomyxoma. The patient was treated with a GnRH agonist followed by surgical excision.

Conclusion. We highlight the novel use of a GnRH agonist as a neoadjuvant to surgery in aggressive angiomyxoma to shrink the tumor preoperatively and decrease surgical morbidity.

While definitive treatment of aggressive angiomyxoma is usually surgical, treatment with a GnRh agonist as a neo-adjuvant may be useful to shrink the tumor preoperatively.

Service de Dermatologie, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada

Reprint requests to: Danya Sereda, MD. E-mail:

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©2009The American Society for Colposcopy and Cervical Pathology