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Outcomes After Diagnosis of Vaginal Intraepithelial Neoplasia

Massad, L. Stewart MD

Journal of Lower Genital Tract Disease: January 2008 - Volume 12 - Issue 1 - p 16-19
doi: 10.1097/LGT.0b013e318074f968
Original Articles
Spanish Translation

Objective. To describe presenting characteristics and outcomes after a diagnosis of vaginal intraepithelial neoplasia (VAIN).

Materials and Methods. Histologically confirmed cases of VAIN identified colposcopically after abnormal cytology were reviewed retrospectively. VAIN 1 was managed with observation, office loop excision, or laser ablation; unifocal or clustered VAIN 2,3 was managed with loop excision; and multifocal VAIN 2,3 was managed with laser ablation. Women were followed up cytologically at 6-month intervals. Clearance was defined as 2 consecutive negative cytology results.

Results. Thirty-six cases were identified with adequate follow-up (median = 20 months). VAIN 1 was found in 17 women, VAIN 2 in 8, and VAIN 3 in 11. All VAIN 1 lesions treated with loop excision were cleared, as were 8 of 12 VAIN 1 cases observed without therapy, 5 of 8 cases of VAIN 2, and 7 of 11 cases of VAIN 3. One woman had persistent VAIN 2; all other cases of persistence were low grade. No cases of progression and no treatment complications were identified.

Conclusions. This management strategy seemed to be safe and effective for the control of VAIN.

Vaginal intraepithelial neoplasia can be controlled in most women through a variety of interventions.

Southern Illinois University School of Medicine, Springfield, IL

Reprint requests to: L. Stewart Massad, MD, Department of Obstetrics and Gynecology, Southern Illinois University, PO Box 19640, Springfield, IL 62794-9640. E-mail:

©2008The American Society for Colposcopy and Cervical Pathology