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Immunohistochemical Expression of p16(INK4A) in Normal Uterine Cervix, Nonneoplastic Epithelial Lesions, and Low-grade Squamous Intraepithelial Lesions

Focchi, Gustavo R. A. MD, PhD1; Silva, Ismael D. C. G. MD, PhD2; Nogueira-de-Souza, Naiara C. MSc, PhD2; Dobo, Cristine MSc1; Oshima, Celina T. MSc, PhD1; Stavale, João N. MD, PhD1

Journal of Lower Genital Tract Disease: April 2007 - Volume 11 - Issue 2 - p 98-104
doi: 10.1097/01.lgt.0000245042.29847.dd
Original Articles
Spanish Translation

Objectives. In this study, the authors analyzed the immunoexpression of p16 in high-risk human papillomavirus DNA-negative normal and nonneoplastic cervical epithelia, in low-grade cervical intraepithelial neoplasia (CIN), high-grade CIN, and squamous cell carcinoma.

Materials and Methods. A retrospective study, in which 58 normal cervical hysterectomy samples, 56 nonneoplastic cervical biopsies, 88 CIN 1, 33 CIN 2, 32 CIN 3, and 47 invasive squamous cell carcinoma biopsies, were evaluated for p16 immunoexpression. Human papillomavirus tests were also performed.

Results. p16 immunohistochemistry seems to reveal possible different biological subgroups of lesions among morphologically similar mildly dysplastic cervical epithelia.

Conclusion. Distribution patterns of p16 protein might be useful to predict different outcomes in CIN 1.

P16 immunohistochemistry seems to identify different biologic features in histologically similar CIN 1 lesions.

1Department of Pathology, and 2Department of Gynecology, Federal University of São Paulo (UNIFESP-E.P.M.), São Paulo, Brazil

Reprint requests to: Gustavo R. Focchi, MD, PhD, Department of Pathology, Federal University of São Paulo, São Paulo, Brazil. E-mail:

©2007The American Society for Colposcopy and Cervical Pathology