In this study, the authors analyzed the immunoexpression of p16
in high-risk human papillomavirus
DNA-negative normal and nonneoplastic cervical epithelia, in low-grade cervical intraepithelial neoplasia
(CIN), high-grade CIN, and squamous cell carcinoma.
Materials and Methods.
A retrospective study, in which 58 normal cervical hysterectomy samples, 56 nonneoplastic cervical biopsies, 88 CIN 1, 33 CIN 2, 32 CIN 3, and 47 invasive squamous cell carcinoma biopsies, were evaluated for p16
immunoexpression. Human papillomavirus
tests were also performed.
Results. p16 immunohistochemistry
seems to reveal possible different biological subgroups of lesions among morphologically similar mildly dysplastic cervical epithelia.
Distribution patterns of p16
protein might be useful to predict different outcomes in CIN 1.