This study compared the performance of cervical cytology plus human papilloma virus testing (Pap + HPV) or cervical spectroscopy
(Pap + CS) for identifying high-grade cervical neoplasia
in a high-risk population of women referred for colposcopy.
Materials and Methods.
Each of 113 subjects underwent spectroscopy
, thin-layer cytology, HPV testing
, colposcopy, biopsy when indicated, and/or endocervical curettage. Evaluable data for analysis were collected for 102 of the subjects. Sensitivity and specificity were calculated for both strategies.
Pap + HPV and Pap + CS achieved equivalent sensitivities (95%) for high-grade lesions, with both detecting 17 of 18 histology confirmed cervical intraepithelial neoplasia (CIN) 2+ lesions. Pap + HPV had a specificity of only 27.4% compared with 65.5% for Pap + CS (p
Spectroscopic interrogation of the cervix is equally sensitive and 2-fold more specific than HPV testing
when combined with cervical cytology for identifying high-grade cervical neoplasia