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Primary Malignant Melanoma of the Uterine Cervix: Case Report and Review of the Literature

Mousavi, Azam S. MD2; Fakor, Freshteh MD4; Nazari, Zeinab MD1; Ghaemmaghami, Fatemeh MD2; Hashemi, Farnaz Amouzegar MD5; Jamali, Mansour MD3

Journal of Lower Genital Tract Disease: October 2006 - Volume 10 - Issue 4 - p 258-263
doi: 10.1097/01.lgt.0000229564.11741.4e
Case Reports

Background. Malignant melanoma of the uterine cervix is a rare neoplasm with poor prognosis. Diagnosis is confirmed by immunohistochemical methods and by exclusion of other primary sites of melanoma.

Case. In this paper, we are reporting a case of a 38-year-old patient with a malignant melanoma of the uterine cervix. Diagnosis was made by histological and immunohistochemical method. The tumor was stage IB1 of the International Federation of Gynecology and Obstetrics classification. Chest x-ray and abdominopelvic computed tomography scanning were normal. A radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy was performed. After performing combined radical surgery and irradiation, complete remission of the tumor was achieved. The patient has been followed for 24 months. She is well without any symptoms or signs of recurrence.

Conclusions. Malignant melanoma is usually misdiagnosed specially in the chronic form. The immunohistochemical study is useful for definite diagnosis. Treatment is not well established, and the disease histogenesis has been controversial for a long time.

This report describes a case of malignant melanoma of the cervix and reviews the various medical literature.

1Mazandaran University of Medical Sciences, Sari, Iran, 2Gynecology and Oncology Department, Vali-Asr Hospital, Tehran University of Medical Sciences, Keshavarz Blvd, Tehran, Iran, 3Central Pathology Department, Imam Khomeini Hospital, Tehran University of Medical Sciences, Keshavarz Blvd, Tehran, Iran, 4Gynecology Department, Gilan University of Medical Sciences, Gilan, Iran, 5Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Reprint requests to: Zeinab Nazari, MD, Mazandaran University of Medical Sciences, Sari, Iran. E-mail:

©2006The American Society for Colposcopy and Cervical Pathology