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Six Cases of Women with Diethylstilbestrol in Utero Demonstrating Long-Term Manifestations and Current Evaluation Guidelines

Tedeschi, Candice A. NP1; Rubin, Mary PhD, NP2; Krumholz, Burton A. MD3

Journal of Lower Genital Tract Disease: January 2005 - Volume 9 - Issue 1 - p 11-18
Original Articles

Diethylstilbestrol (DES), a nonsteroidal estrogen, was widely used in the United States from 1940 through 1971 to prevent pregnancy loss. In the late 1960s, an association was made with an increased incidence of clear cell adenocarcinoma in young women exposed in utero to DES. Additional study of these women over the next 35 years has shown an increased risk of other health problems including intraepithelial neoplasia, ectopic pregnancy, first trimester spontaneous abortion and second trimester pregnancy loss. The National Institutes of Health continues to fund studies to follow cohorts of DES-exposed mothers, daughters, sons and third generation children. The Centers for Disease Control have conducted a large DES Education Project and have established guidelines for management. The following six cases studies illustrate common problems seen in DES exposed daughters and management of problems encountered.

DES-exposed women continue to have gynecological and obstetrical problems that are illustrated in six case studies.

1CDC DES Education Project, Great Neck, NY; 2University of California, San Francisco, San Francisco, CA; 3Long Island Jewish Medical Center, New Hyde Park, NY

Reprint requests to: Candice Tedeschi, 5 Hickory Lane, Glen Cove, NY 11542. E-mail:

©2005The American Society for Colposcopy and Cervical Pathology