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Langerhans Cell Histiocytosis of the Vulva: Two Case Reports

Dietrich, Jennifer E. MD1; Edwards, Creighton MD1; Laucirica, Rodolfo MD2; Kaufman, Raymond H. MD1,2

Journal of Lower Genital Tract Disease: April 2004 - Volume 8 - Issue 2 - p 147-149
Case Report

Abstract: This report describes the histopathologic results of Langerhans cell histiocytosis of the vulva and options for treatment. We present two new cases demonstrating vulvar manifestations of disease and their course of treatment with a review of the literature. Langerhans cell histiocytosis of the female genital tract is rare. The disease cannot be diagnosed without biopsy of cutaneous lesions. Langerhans cell histiocytosis of the vulva is a rare disorder with few options for treatment.

Langerhans cell histiocytosis of the vulva is a histologically diagnosed disease in which treatment has little impact on the disease course.

Department of 1Obstetrics and Gynecology and 2Pathology, Baylor College of Medicine, Houston, TX

Reprint requests to: Jennifer E. Dietrich, MD, Department of Obstetrics and Gynecology, Baylor College of Medicine, 6500 Fannin, Suite 901, Houston, TX 77030. E-mail:

©2004The American Society for Colposcopy and Cervical Pathology