ReviewsResistant hypertensionKaplan, Norman MAuthor Information Department of Internal Medicine, Division of Hypertension, The University of Texas, Southwestern Medical Center, Dallas, Texas, USA Received 18 March, 2005 Revised 17 May, 2005 Accepted 23 May, 2005 Correspondence and requests for reprints to Norman M. Kaplan, M.D., Clinical Professor, Department of Internal Medicine, Division of Hypertension, The University of Texas, Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8899, USA. Tel: +1 214 648 2103; fax: +1 214 648 7979; e-mail: Norman.Kaplan@UTSouthwestern.edu Journal of Hypertension: August 2005 - Volume 23 - Issue 8 - p 1441-1444 doi: 10.1097/01.hjh.0000174968.72212.ac Buy Metrics Abstract Hypertension that remains above 140/90 mmHg despite the use of three antihypertensive drugs in a rational combination at full doses and including a diuretic is known as ‘resistant’. The percentage of hypertensives whose condition is resistant varies in large part upon the setting: those seen in general practice show a prevalence of perhaps 5%; those seen by nephrologists, probably 50%. This paper reviews the major causes of resistant hypertension and provides specific recommendations for the evaluation and management of patients with this threatening condition. © 2005 Lippincott Williams & Wilkins, Inc.