Ginkgo Biloba is described in literature as a herbal remedy with low rate of adverse evens, good pharnakokinetic properties and limited number of inter-drug interactions in complex treatment of variety of diseases which application has some benefit in patients with arterial hypertension (AH)
We observed 43 patients with arterial hypertension (no other illnesses in exacerbation). female-male ratio 1:1, average age - 53,6 years old. Ambulatory blood pressure (BP) monitoring was conducted to them on 1st day after admission to the hospital (before medication prescribtion) and after one month of application of treatment. 22 patients comprised main group - they obtained basic therapy (lisinopril 10 mg QD, ASA 75 mg QD) and gingko biloba extract 1 tab TID. 21 patient was included into control group, who were prescribed basic therapy only.
BP decrease in main group versus control was observed (average daily systolic BP was 8.8,5% (p < 0,05) vs 4.5% lower comparing initial values. Difference of systolic BP vs control was more prominent after 1 month of treatment - 18,2% (p < 0,05) vs 8,2% (p < 0,05). Significant and equal decrease of diastolic BP was observed in both groups at the end of treatment visit. Average day systolic BP decreased equally in both groups. On the contrary, average night BP decreased by 6.9% in main group and by 3.8% only in control.
Ginkgo biloba extract posesses antihypertensive properties, is well tolerated and should be included into treatment schedule of patients with AH.