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9 THE CORRELATION AMONG HYPERTENSION, REDUCTION OF GLOMERULAR FILTRATION RATE AND HYPERURICEMIA IN BATU CITY'S POPULATION OF FARMER

Fadlan, Muhamad Rizki1; Maharani, Andona Murni2; Sargowo, Djanggan1,2

Journal of Hypertension: July 2018 - Volume 36 - Issue - p e3
doi: 10.1097/01.hjh.0000544374.19420.67
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Background: Many studies were found correlation between hypertension, hyperuricemia and reduction of glomerular filtration rate in general population but little or no information was found correlation in farmer's population.

Objective: To explore the correlation between systolic blood pressure (SBP), diastolic blood pressure (DBP) and Glomerular Filtration Rate (GFR) with serum uric acid levels in specific population (Batu City's Farmer).

Method: It was observational analytic among specific population with cross sectional method. A total of 102 subjects from farmer in Bumi Aji Village, Batu City. All participants were individually interviewed with a structured questionnaire and measured according to standard protocol Fasting blood samples were then collected for the measurement of uric acid, glucose, lipids and creatinine. The levels of correlation between variables were determined by calculating Pearson's correlation coefficients (r).

Result: There were 82 subjects (77%) female, mean age 46,7 ± 10,4, mean uric acid 5,6 ± 1,54, prevalence of hyperuricemia 30,4%, mean Systolic Blood Pressure 124 ± 19,4, mean diastolic blood pressure 80,5 ± 13,2 Mean GFR 90,5 ± 29,06. In subject with hyperuricemia display significantly higher SBP (p = 0,016), higher DBP (p = 0,008), higher triglyceride (p = 0,01) lower HDL (p = 0,026). Pearson correlation showed that hyperuricemia correlate with increase systolic blood pressure (r = 0,41, p = 0,000), increase diastolic blood pressure (r = 0,43, p = 0,000), Increase Triglycerides (r = 0,39, p = 0,000), low HDL level (r = −0,244, p = 0,007,).

Conclusions: In this study, we suggest that serum uric acid has significant correlation with levels of blood pressure and weak correlation with GFR reduction. Further investigation is required to establish the treatment for hyperuricemia in hypertensive patients.

1Cardiovascular Department Faculty of Medicine Brawijaya University-dr.Saiful Anwar General Hospital, Malang East Java, Indonesia

2Center Study of Degenerative Disease, University of Brawijaya

Keywords: Systolic blood pressure; Diastolic blood pressure; Uric acid; Triglycerides

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