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25 INVESTIGATING VASCULAR DISEASES AS RISK FACTORS OF MEMORY IMPAIRMENT IN ELDERLY

Turana, Yuda1; Suswanti, Ika1; Sani, Tara P1; Suryakusuma, Linda1; Handajani, Yvonne S2

doi: 10.1097/01.hjh.0000544390.51700.81
12th INASH ABSTRACT BOOK
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Introduction: Vascular risk has been reported as a predictor of overall cognitive decline and a diagnosis of mild cognitive impairment (MCI). We investigated the association between vascular risk and memory impairment (MI) in elderly people.

Methods: This was a case-control study involving 544 participants aged ≥ 60 years from Atma Jaya Cognitive and Aging (ACtive Aging) Research. A positive vascular risk was identified as having a history of heart attack, hypertension, or diabetes and/or a low HDL or high LDL level obtained from blood sample. We used the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) instrument to assess the cognitive function of the respondents. MI was defined as a score of WLMIR trial 3 less than 8.

Result: Mean age of the participants was 66.29 ± 7.89. A majority of the participants was classified as having MI (76.1%). There was no association between MI with gender or history of heart attack, hypertension, diabetes, or lipid profile (p > 0.05). Strong associations were found between MI and both education and age (p < 0.005, OR: 2.136, OR:1.964),

Conclusion: MI was not associated with vascular risk. The odds of MI were more likely to increase along with aging and inversely associated with education.

1Department of Neurology, Faculty of Medicine, Atma Jaya Catholic University of Indonesia

2Center of Health Research, Atma Jaya Catholic University of Indonesia

Table 1 Description of Participants' Characteristics

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Table 2 Participants' Demographics Characteristics, Vascular Risk, and Memory Impairment

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