Analyze if during a Hypertensive Urgency (HU) there is a biomarker that can increase, suggesting early cardiac inflammation in asymptomatic patients. It‘s well known that the pro-BNP is a trustworthy biomarker of cardiac inflammation and remodeling.
Prospectively consecutive adult patients with HU (Blood pressure ≥180/110) were enrolled. A blood sample, to measure the pro-BNP, was drawn immediately the patient arrived to the Emergency Room (ER). Patients with known cardiovascular disease and pregnant women were excluded. Summary statistics are presented as the mean and standard deviation (SD). The relationships between BNP and BP, age and sex was assessed using Pearson's correlation coefficient.
Were studied 125 patients, (63 were women) the mean of age was 59 years (DS 12.9). The mean of pro-BNP was 202.44 pg/mL (DS 253.9). The mean of pro-BNP distributed by sex was 142 for men and 261 for women with a statistically significance of p = 0.001. There is also a positive correlation between Age and pro-BNP r = 0.31. There was a positive correlation between Systolic Blood Pressure and pro-BNP levels with r = 0.3, p = 0.01.
In patients with HU there is a modest elevation in pro-BNP level that can help us to suspect early cardiac inflammation. It can allow the physicians to identify those patients who will benefit from more complementary tests and aggressive management.
Department of Emergency Room, Emergency, Spain