The cardiovascular haemodynamics has been extensively studied for several centuries [1–4]. One of the major representatives in the field at the end of the nineteenth century was Otto Frank who contributed to arterial mechanics with the mathematical formulation of the Windkessel effect . The Windkessel model shows the importance of aortic compliance in turning the pulsatile cardiac output into a more steady flow in the microcirculation; about half of the stroke volume is stored during systole in the compliant arteries which recoil during diastole forwarding it through the microcirculation much more steadily . The model consists of a resistance to flow through the microcirculation (R) that depends on the peripheral vessels, and a compliance (C) determined mainly by the elasticity of the large arteries. The model predicts that the arterial pressure will decay exponentially during diastole with a time constant RC. The Windkessel model, as originally presented, describes the diastolic part of the pressure waveform very well, but is not accurate for systole because it does not take into account the contribution of the waves . The addition of the characteristic impedance to the two-element Windkessel was proposed to link the lumped model and the wave propagation in the arterial system [8,9].
Another technique for studying arterial waves is wave intensity analysis (WIA), which is a time-domain technique based on the classical one-dimensional flow equations in flexible tubes, and was introduced as an alternative to the frequency-domain techniques [10,11]. Both WIA and impedance methods can be used for the separation of pressure and flow waveforms into their forward and backward components, producing results that are almost identical . WIA, however, has the advantage that it does not rely upon the assumption of periodicity that is essential for Fourier analysis techniques . WIA has been extensively used in the human aorta , in the radial vessels  and more recently non-invasively in the carotid artery . Whilst WIA seems to describe the pattern of waves and their intensities very well, the aortic ‘reservoir effect’ is not taken into account.
There are some anomalies in the separation of arterial pressure into its forward and backward components using either impedance or WIA . This is particularly noticeable during diastole when inflow into the proximal aorta is nearly zero, but pressure decays exponentially. Thus, any linear separation technique, such as WIA or impedance analysis, will result in forward and backward pressure with nearly equal magnitudes in this period. This could be realized by standing waves in the aorta, but other evidence, such as the extended exponential pressure decay during extended diastole due to ectopic or missing heart beats, mitigates against them (Fig. 6 in ).
The first time-domain approach to couple the reservoir effect and the wave propagation theory at the aortic root was proposed by Wang et al.. The reservoir-wave model was extended to the venous system  and was further developed for any arbitrary location in the arterial system . This model is based on the heuristic assumption that the measured pressure in the aorta (P) is the sum of a reservoir pressure (Pr), due to the storage of blood in the compliant aorta during systole and its discharge in diastole, and an excess pressure (Pe), due to the waves. This new approach resolves the self-cancelling waves that appear in the separation of the flow waveforms using the measured pressure [20,21]. The subtraction of the reservoir pressure, which accounts for the potential energy stored in the aorta, allows the study of wave propagation employing WIA using Pe instead of P. Since the Windkessel function seems to improve left ventricle relaxation  and coronary blood flow , the study of the buffering function of the aorta in terms of Pr could be a useful tool to better understand the mechanics of the heart and the coronary circulation. The reservoir-wave model has been applied to humans , animals  and numerical data .
Although the reservoir-wave model is based on the in-vivo observations of uniform diastolic decay with a time lag downstream t, some authors have questioned the validity of this technique [25,26]. Mynard et al. showed that the use of Pe for determining the intensity of the waves leads to a reduction or elimination of the backward compression waves and to an increase or artefactual introduction of the expansion waves. On the contrary, Wang et al. demonstrated that the wave pattern after subtraction of Pr is more physiologically consistent than that calculated using traditional WIA. As a contribution to the ongoing debate regarding the two models, we assessed in this work the similarities and differences between the results of the two models, and considered physiological explanations based on the anatomy of the arterial system.
Previous studies [17,18] have shown that the reservoir-wave approach yields small values of backward waves in normal conditions. However, this approach has not been adequately investigated in the presence of large reflections that are quantified using the wave-only approach. Also, since the subtraction of the reservoir pressure from the measured pressure results in a pressure component due to waves, which is significantly different in shape than that measured at the same location , we hypothesized that using the reservoir-wave model would produce different values of wave speed, assessed by the PU-loop method, and intensity, assessed using WIA, than those produced using the measured pressure. Therefore, the aim of this work is thus to provide a detailed, quantitative study of the differences in wave speeds and wave intensities when arterial flow properties are calculated using P, wave-only model, and using Pe, reservoir-wave model. The data are from measurements in the canine ascending aorta when the effects of total occlusion at four different sites were studied . This enables us to study the effect of the reservoir pressure in normal conditions and in conditions in which enhanced reflected waves are certain to be present, similar to those expected in pathophysiological conditions such as arterial stiffness and hypertension.
MATERIAL AND METHODS
Wang et al. proposed that the measured ascending aorta pressure can be considered as the sum of a reservoir pressure (Pr) and an excess pressure (Pe), where Pr accounts for the Windkessel effect and Pe accounts for wave effect.
Following a recent study , we define P(x,t) = Pr[t – τ(x)] + Pe(x,t), where τ(x) is the time of wave propagation from the aortic root (x = 0) to the location x in the arterial system. Since τ = 0 at the aortic root, this definition is consistent with the previous study  analysing flow in the aortic root, but extends the concept to other parts of the arterial system in a way that overcomes the obvious objection that the reservoir pressure cannot be uniform throughout the arterial system (as assumed in the simple Windkessel model) because arterial wave speeds are finite.
Conservation of mass requires
where Vr is the reservoir volume, Qin is the aortic inflow and Qout is the outflow. We assume that the aortic reservoir has a constant compliance, C, and that the flow out of the arteries can be described by a simple resistance relationship:
where P∞ is the asymptotic pressure of the diastolic exponential decay. This may be the venous pressure or may be determined by the interstitial pressure due to the waterfall effect. The mass conservation equation can then be written in terms of Pr as
This has the general solution
where t0 and P0 are time and pressure at the beginning of the ejection. Qin is 0 during diastole by definition and so the reservoir pressure during diastole will simply fall exponentially.
The alternative arterial wave propagation theory (wave-only model) is derived from the one-dimensional conservation of mass and momentum equations which can be solved by the method of characteristics . This solution states that any disturbance in the vessel will generate wave-fronts that travel in the forward and backward direction with speed U ± c. Changes in pressure (dP) and velocity (dU) in these waves are related through the water hammer equation
where ρ is the fluid density, c the wave speed and ‘±’ refers to the wave direction. The wave intensity, dI = dPdU, was introduced by Parker et al. as a measure of the energy flux carried by the waves.
Khir et al. introduced the PU-loop method for the determination of c based on Eq. (6). If the wave speed (or equivalently the characteristic impedance) is known, it is possible to separate the measured pressure and velocity waveforms into their forward and backward components. This can be done either using impedance  or WIA . Using the water-hammer equation [Eq. (6)] with the assumption that the forward and backward waves are additive, it can be shown that
where P0 is the integration constant chosen arbitrarily as diastolic pressure in the (+) and 0 in the (−) directions, respectively. Also,
where U0 is the integration constant taken as 0 in both the (+) and (−) directions.
It follows that the forward and backward wave intensity are
Note that the separation technique depends upon the knowledge of the wave speed c.
Experiments were performed in 11 anaesthetized mongrel dogs (average weight 22 ± 3 kg, 7 males). The experimental protocol is described in Khir and Parker . The dogs were anaesthetized with sodium pentobarbital, 30 mg/kg-body weight intravenously, and a steady dose of 75 mg/h was given throughout the experiment. The dogs were endotracheally intubated and mechanically ventilated using a constant-volume ventilator (Model 607; Harvard Apparatus Company, Millis, Massachusetts, USA).
To measure the flow rate, an ultrasonic flow probe (Flow meter model T201; Transonic Systems Inc., Ithaca, New York, USA) was fitted around the ascending aorta approximately 1 cm distal to the aortic valve leaflets. Pressure at the aortic root, just downstream of the flow probe, was measured with a high-fidelity pressure catheter (Millar Instruments Inc., Houston, Texas, USA) inserted from the right or left brachial artery. Snares were placed at four different sites: the upper descending thoracic aorta at the level of the aortic valve (thoracic); the lower thoracic aorta at the level of the diaphragm (diaphragm); the abdominal aorta between the renal arteries (abdominal) and the left iliac artery, 2 cm downstream from the aorta iliac bifurcation (iliac). The right iliac artery was occluded throughout each experiment to allow the insertion of a transducer-tipped pressure catheter used for measuring the pressure upstream each occlusion. Data were collected for 30 s before the occlusion (control) and during the occlusion; 3 min after the snare was applied. An interval of 10–15 min was allowed between each occlusion in order to return to control conditions . The sequence of the four occlusions was varied between dogs using a 4×4 Latin-square to remove possible time effects. The circumference of the ascending aorta was measured post mortem to derive the diameter required to convert the measured flow rate into velocity. All data were recorded at a sampling rate of 200 Hz and stored digitally. The relative time delay between P and U signals due to the phase differences of the transducers and to the small displacement between their locations was eliminated by the appropriate shifting of the velocity signal .
The reservoir pressure was calculated using an algorithm similar to that described by Aguado-Sierra et al.. Briefly, the start of diastole is defined as the time of the first point of inflection in the measured pressure after the systolic peak. The diastolic pressure is fitted to the model P(t) − P∞ = (P0 − P∞) e−t/RC, where P0 is the pressure at the start of diastole, to find the time constant RC and the asymptotic pressure P∞. The method is based on the two assumptions that the arteries are well matched for forward waves and the volume flow rate into the aorta is proportional to the excess pressure Pe(t). The value of this constant of proportionality is determined iteratively by minimizing the mean square error between the model and the measured pressure during the whole cardiac period. Given this constant, Pr(t) and Pe(t) can be calculated directly. In Table 1, the averaged values of measured pulse pressure (ΔP), reservoir pulse pressure (ΔPr) and excess pulse pressure (ΔPe) are reported together with the averaged value of diastolic pressure (Pd).
Wave speed in the ascending aorta was determined from the slope of the linear part of the PU-loop (c) and the PeU-loop (ce), before and during total occlusion. The net wave intensity was calculated using P(dI) and Pe(dIe) in all of the experimental conditions and then was separated in forward (dI+, dIe+) and backward (dI−, dIe−) wave intensity. In all cases, the forward wave intensity displayed a positive peak at the start of systole, indicating a forward compression wave (FCW) and another at the end of systole indicating a forward expansion wave (FEW). In some conditions, a negative peak in the backward wave intensity was discernible during mid-systole indicating a backward compression wave (BCW). The magnitude of the forward peaks (dIFCW, dIeFCW and dIFEW, dIeFEW) and backward peaks (dIBCW, dIeBCW), and the reflection indices (RI and RIe), calculated as dIBCW/dIFCW and dIeBCW/dIeFCW, were determined. Also, the time of the peaks (tFCW, teFCW, tBCW, teBCW, tFEW, teFEW) and the onset time of the backward compression (tBCWonset, teBCWonset) and forward expansion waves (tFEWonset, teFEWonset) were determined using the two models, and the results were compared. Wave speed and intensity calculated with P and Pe before and during the total occlusion are the average of all cardiac beats over the 30-s period of measurement. Four control recordings were sampled in each dog, one before each occlusion. Since there were no significant differences between these four control measurements, they were pooled for each dog and considered as the control state. Data are presented in the text and tables as mean values ± SD (mean was calculated by averaging the mean values of all dogs). Paired two-sided t tests were used to assess differences between parameters calculated using P and Pe. Paired t tests were also used to assess differences between parameters calculated during control and occlusion conditions. The relationship between ΔPr and stroke volume Vin(calculated by integrating the area of under the flow waveform during systole) was assessed using bivariate correlation. Values of P less than 0.05 were considered statistically significant. Statistical analyses were performed using SPSS 17.0 (SPSS Inc., Chicago, Illinois, USA).
There is a significant difference in the morphology of the PU and PeU loops in all cases. The PU-loop is a distinct loop with large hysteresis between the systolic and diastolic portions of the curve. The PeU-loop exhibits much less hysteresis, and in many cases, such as the control conditions shown in Fig. 1, the loop collapsed almost completely to a single curve. In all cases, the early systolic portion of the loop was linear, enabling a measurement of the wave speed from the slope. In every condition, the wave speed determined from the PU-loop, c, was greater than the wave speed determined from the PeU-loop, ce, and all of the differences were statistically significant. The values of c and ce and their ratio are reported for all conditions in Table 2. We see that c during the thoracic occlusion is significantly higher than the control conditions (9.9 ± 2.5 vs. 6.0 ± 2.6 m/s; P < 0.05). ce calculated during the thoracic occlusion was not statistically different from control. There were no significant differences between either c or ce, during any of the other occlusions compared to control conditions.
Wave intensity and reflection index
As seen in Fig. 2, there were both similarities and differences between the wave intensity calculated with P, dI = dPdU, and with Pe, dIe = dPedU. In all cases, the forward wave intensities, dI+ and dIe+, were similar in shape with large peaks at the start (FCW) and end (FEW) of systole. As discussed below, the morphology of these peaks was unchanged, but there were differences in their magnitudes. However, the backward wave intensities, dI− and dIe−, showed large differences with the no peaks discernible in the dIe− waveforms for many of the cases. The magnitude of the three main wave intensity peaks, dIFCW, dIFEW, dIBCW, dIeFCW, dIeFEW and dIeBCW and their ratios are reported in Table 2. For both of the forward waves, FCW and FEW, dI > dIe and the difference are statistically significant in all cases except for the thoracic and diaphragm occlusions for the FEW wave. The results for the BCW are qualitatively different from the results for the forward waves. In all cases, dIe << dI, with the differences being highly significant statistically. The reflection index, which is related to the effective reflection coefficient, shows a similar pattern. For control conditions, the difference between RI and RIe is large and statistically significant, as reported in Table 2.
The times of the forward and backward peak intensities and the times of the onset of the BCW and FEW when calculated using the wave-only and the reservoir-wave models are reported in Table 3. As can be seen from the table, there is no significant difference in timing between the two analyses in all conditions, apart from the time of the onset of the FEW that comes earlier when the analysis is performed with Pe, both in control and during the four occlusions.
A comparison of wave intensities and reflection indices between occlusion and control conditions yielded a broadly similar pattern. For both the FCW and the FEW, there is a slight but statistically significant decrease in the peak values of dI when the occlusion is in the thoracic and diaphragm position, and no significant differences when the occlusion is in the more distal locations. This is true for the wave intensity calculated using the measured pressure dI or the excess pressure dIe. For the BCW, there is a large and highly significant increase in the dI for the thoracic occlusion, an even larger increase for the diaphragm occlusion and no significant difference for the abdominal and iliac occlusions. Although dIe is significantly smaller than dI for all of the cases, this pattern persists for dIe: a significant increase for the thoracic occlusion, an even larger increase for the diaphragm occlusion and no differences for the two more distal occlusions.
The reflection index shows this pattern more clearly. For the reflection index calculated using P, RI is more than double for the thoracic occlusion, more than triple for the diaphragm occlusion and is not significantly different from control conditions for the abdominal and iliac occlusions (Table 2). The reflection index calculated using the Pe, RIe, is significantly smaller than the correspondent RI, but follows the same pattern: a large increase for the thoracic occlusion, an even larger increase for the diaphragm occlusion and no significant difference from control conditions for the two more distal occlusions.
Reservoir and excess pressure
The P, Pr and Pe values in the ascending aorta for a typical case are shown in Fig. 3. As seen in the figure, the aortic pressure increased significantly when the occlusion was in the thoracic aorta. The averaged values of measured, reservoir and excess pulse pressures (ΔP, ΔPr and ΔPe, respectively) and diastolic pressure Pd for all conditions are reported in Table 1. As can be seen from the table, ΔP and ΔPr are significantly higher during thoracic occlusion compared to the control, whereas ΔPe does not change significantly compared to the control state for all the other occlusion conditions.
Figure 4 shows the relationship between the reservoir pulse pressure (ΔPr) and the stroke volume (Vin) in control condition and during the occlusions for each dog. The Pearson correlation factors between these two parameters were 0.70, 0.83, 0.87, 0.70 and 0.72 in control and during thoracic, diaphragm, abdominal and iliac occlusion (P < 0.05 in all conditions). The slope of the linear regression is higher for the thoracic occlusion than the control, even higher for the diaphragm occlusion, but not significantly different from the control for the abdominal and iliac occlusions. A similar relationship is also found between pulse pressure and stroke volume (correlation factors were 0.76, 0.85, 0.87, 0.78 and 0.74 for control and occlusions; P < 0.05 in all conditions).
The study compares various haemodynamic parameters in the canine ascending aorta calculated using P and Pe. The data used in our analysis were originally generated to investigate haemodynamics in the ascending aorta using WIA, and the experiment has been designed to provide definitive reflection sites at different locations along the aorta to increase the magnitude of reflected waves seen in the ascending aorta . In the present study, the reservoir-wave model is applied for the first time in these atypical conditions, and the similarities and differences between this model and the wave-only model are investigated.
The separation of the pressure waveform using the reservoir-wave technique has shown that Pe and the flow waveform are identical in shape, and their peaks occurred simultaneously as demonstrated in Fig. 1. of the study by Wang et al.. However, traditional wave separation indicated that peak of forward wave (P+) always occurred later than peak of the flow waveform. This time difference results in differences only in the onset of the FEW and no significant differences in the timing of the WIA parameters between the two analyses in our experiments. The difference in time of peak P and Pe was also considered in relation to the determination of wave speed. The PU-loop method relies on the determination of the slope of the initial linear part of the loop, which usually ends before the time of peak P or U. This means that the differences between ce and c observed in this study, with ce always smaller than c, do not depend on the time of pressure (P or Pe) or velocity peaks. Nevertheless, wave speed is known to be a direct measure of arterial stiffness and is theoretically expected to have the same value when measured in the same system under the same conditions, even when determined using different techniques. However, a gold standard method for the determination of the local wave speed has not been established yet, and therefore it is not possible at this stage to state with confidence which of the tested techniques in this study yields a more correct value.
A possible explanation for our results can be found considering the meaning of the reservoir pressure. This pressure component is defined as a time-dependent response of the arteries to flow ejected from the heart arising from the net compliance of the arteries. It is assumed to be uniform in shape throughout the system, but delayed by a time that is related to the wave travel time from the root of the aorta . Although it appears to be propagating into the arterial system, it is not a simple forward travelling wave, but the summation of myriad forward and backward waves produced by the reflection and re-reflection of the waves generated by the ventricle. The theory behind the determination of the wave speed by the slope of the PU-loop assumes that there are only forward waves during early systole. If the reservoir pressure is made up of forward and backward waves, then it can be argued that the excess pressure, the difference between the measured and the reservoir pressure, will better satisfy the assumption that only forward waves are included in the PeU-loop and may result in a more plausible estimate of the wave speed. Since the slope of the reservoir pressure is invariably positive in early systole, subtracting it from the measured pressure will reduce the slope of the PeU-loop during that time. As a result, the wave speeds estimated from the PeU-loop are smaller than those estimated from the PU-loop.
The wave intensities calculated for the three main waves, FCW at early systole, FEW during late systole and BCW during mid-systole, are reported in Table 2. In every case, the magnitude of dIe was less than that of the corresponding peak of dI. Despite the decrease in the magnitude of the wave intensity calculated using Pe, the time and pattern of the magnitudes of the main waves measured during the different occlusions were remarkably similar. The notable exception is the arrival time of the FEW, where the arrival time is earlier when calculated from dIe than for dI (Table 3), because the maximum of Pe generally occurs earlier than the maximum of P.
Another finding, common to the two methods, is that the averaged values of RI during diaphragm occlusions are slightly higher than during the thoracic occlusion (Table 2), and in some dogs, reflections due to the diaphragm occlusion are bigger than these due to the thoracic occlusion. A possible explanation of our result is that during this proximal occlusion, the aortic arch branches (subclavian and brachiocephalic arteries) play a greater role than during the diaphragm occlusion. Westerhof et al. previously suggested that the behaviour of the aorta clamped at the diaphragm level is more similar to a uniform tube with a closed end compared to the aorta occluded at a more proximal location, such as the thoracic level. The authors explained this finding by considering the uniform tube when clamped proximally as ‘short-circuited’ because of the considerable role of the cephalic vessels and collaterals in this condition.
The reflected waves have been used clinically/physiologically as a marker of arterial stiffness , thought to play a major role in the shape of the pressure waveform and in the determination of the augmentation index (AIx), which is a correlate of mortality. However, recent studies questioned the size and role of reflected waves. Sharman et al. found a disparity between the traditional explanation for the shape of the pressure waveform, due to reflected waves, and the reservoir-wave approach. The authors suggested the role of the reflected waves in the determination of AIx may have previously overstated. Davies et al. demonstrated that arterial reservoir increases with age and it is a major determinant of aortic AIx, which they found not to be predominantly a measure of wave reflection. The authors concluded that aortic pressure waveform is more related to the reservoir function than the wave reflection. Tyberg et al. reported the magnitude of the peak-reflected pressure wave when using the reservoir-wave model is approximately 6% of the total pressure, whereas it would be approximately 30% of total pressure using the wave-only model. Our results agree with the above studies, and the decrease of the backward compression wave intensity calculated using Pe is one of the most significant results of this study. Similar results about the reduction of backward compression waves using the reservoir-wave model compared to the wave-only model have been recently reported by Mynard et al.. The authors performed WIA in computational and animal data and found lower values of backward compression waves and reflection coefficient when the reservoir-wave system was applied compared to the traditional WIA. These results are in line with our findings. However, they also found bigger backward expansion waves using the reservoir-wave approach that were not present in our work.
Despite the reduction in the magnitude, dIeBCW and dIBCW showed a similar pattern with significant reflections during the more proximal and no reflections from the more distal occlusion. The small magnitude of the backward travelling waves found using the reservoir-wave model can be explained if we consider that the arterial system is well matched in the forward but not in the backward direction [36–39]. We calculated the reflection coefficients from the trifurcation of the aortic arch in forward direction as
and for the backward direction as
where Y0, Y1,Y2, Y3 are the characteristic admittances (Y = 1/Z = A/ρc) for the ascending aorta, brachiocefalic artery, left subclavian artery and descending aorta, respectively. These values were calculated using the characteristic impedances for the different vessels reported by Cox and Pace  in anaesthetized dogs in control condition, in which values of vascular impedance have been calculated by averaging between 8 and 15 Hz. We found that the reflection coefficient is 0.02 in the forward direction and −0.48 in the backward direction. This means that approximately half of the energy carried by a backward wave in the thoracic aorta will be reflected at the aortic arch. This may be the main reason for the observation of small backward waves at the aortic root, even during the occlusion, using the reservoir-wave model.
The pulse of the reservoir pressure is strongly related to the stroke volume as shown in Fig. 4. In particular, a different linear relationship can be observed during occlusion of the aorta at the thoracic and diaphragm level compared to the control for Pr and Pe, caused by the different pulse pressure in these conditions.
Davies et al. studied the contribution of Pr and Pe in humans in relation with age. They found that the contribution of the reservoir pressure to the increase of AIx with age is larger than that of the reflected wave contribution as previously thought [41,42]; the increase is largely due to the decrease of the aorta compliance and other elastic vessels. Our results are related to their findings since the increase of pulse pressure due to the thoracic occlusion can be compared to the increase of pressure due to age or to cardiovascular diseases such as hypertension. Our findings confirm that the reservoir pressure makes a larger contribution to the pressure waveform than the excess pressure, shown in Table 1, as previously reported by other authors [24,43].
In conclusion, the reservoir-wave and the wave-only models produce similar WIA curves, although the magnitudes are strikingly different. Both models lead to the conclusion that aortic occlusions downstream the diaphragm level have little or no effect on haemodynamics in the ascending aorta. The models yield different values of wave speed and different wave magnitudes, despite using the same analytical techniques of the pressure-velocity loop and WIA. The reservoir-wave model always yields lower values for all haemodynamic parameters studied. The small magnitude of BCW in the aortic root during occlusions, using the reservoir-wave model, could be explained by considering the geometry of the aortic arch which has different magnitude of reflection coefficients in the forward and backward directions, although this requires a larger study to confirm this observation. The differences found between the results of wave speed and WIA based on the measured pressure and the reservoir/excess pressures do not mean that the values based on excess pressure are erroneous. In the absence of other independent techniques or evidence, it is not currently possible to decide which of the two models compared in this study is more correct.
Alessandra Borlotti received the Isambard doctoral scholarship offered by Brunel University London, for which we are grateful.
Conflicts of interest
There are no conflicts of interest.
Reviewers’ Summary Evaluations Reviewer 2
The determinants of the components of the aortic pressure waveform are assessed using wave intensity and windkessel models. The two models give different values of pulse wave velocity for the same vessel. This suggests a model-dependent interpretation for the same haemodynamic phenomena regarding the contribution of wave reflection to the pressure waveform. However, from the data presented in the study it is not possible to ascertain which model gives a more fiducial interpretation.
The strengths of the study are the comprehensive conceptual models to assess arterial hemodynamics.
The basic problem of understanding arterial pulse wave dynamics is challenging altogether.
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