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Effect of green tea supplementation on blood pressure among overweight and obese adults: a systematic review and meta-analysis

Li, Guoweia; Zhang, Yuana; Thabane, Lehanaa,b; Mbuagbaw, Lawrencea; Liu, Aipingc; Levine, Mitchell A.H.a,b; Holbrook, Annea,b

doi: 10.1097/HJH.0000000000000426
REVIEWS AND META-ANALYSES

Background: Emerging randomized controlled trials (RCTs) investigating the effect of green tea or green tea extract (GTE) supplementation on blood pressure (BP) among overweight and obese adults reported inconsistent findings.

Objective: To conduct a systematic review and meta-analysis to clarify the efficacy of green tea or GTE on BP among overweight and obese adults.

Methods: Electronic databases, conference proceedings and gray literature were searched systematically to include parallel and cross-over RCTs examining the efficacy of green tea or GTE on BP compared with placebo. Data were meta-analyzed using a random-effects model, to compare the mean difference of the change in BP from baseline in the intervention and the placebo groups.

Results: Fourteen RCTs with 971 participants (47% women) were pooled for analysis. Green tea or GTE produced a significant effect on both SBP (mean difference −1.42 mmHg, 95% confidence interval −2.47 to −0.36, P = 0.008; I 2 = 52%, P = 0.01 for heterogeneity) and DBP (mean difference −1.25 mmHg, 95% confidence interval −2.32 to −0.19, P = 0.02; I 2 = 74%, P < 0.001 for heterogeneity), compared with placebo. The quality of evidence across studies was low. Similar results were found in subgroup and sensitivity analyses.

Conclusion: Among overweight and obese adults, green tea or GTE supplementation is found to cause a small but significant reduction in BP. More high-quality RCTs with large sample sizes are needed to further confirm the efficacy on BP and make strong recommendations for green tea or GTE supplementation among the overweight and obese adults.

Supplemental Digital Content is available in the text

aDepartment of Clinical Epidemiology and Biostatistics

bSt Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada

cDepartment of Social Medicine and Health Education, Health Science Center, Peking University, Beijing, China

Correspondence to Guowei Li, MD, MSc, PhD(c), Department of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada. Tel: +1 905 962 1068; fax: +1 905 308 7386; e-mail: lig28@mcmaster.ca

Abbreviations: BP, blood pressure; CI, confidence interval; EGCG, epigallocatechingallate; GTE, green tea extract; PRISMA, preferred reporting items for systematic reviews and meta-analyses; RCT, randomized controlled trial

Received 26 May, 2014

Revised 17 September, 2014

Accepted 17 September, 2014

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.jhypertension.com).

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