aDepartments of Clinical Pharmacology and Therapeutics
bPlanning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai
cTohoku University 21st Century COE Program ‘Comprehensive Research and Education Centre for Planning of Drug Development and Clinical Evaluation’, Sendai, Japan
*For details of the J-HOME Study Group, see .
Correspondence and requests for reprints to Takayoshi Ohkubo, Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Hospital, Sendai 980-8574, Japan Tel: +81 22 7178590; fax: +81 22 7178591; e-mail: email@example.com