aDepartment of Physiology, Nanjing Medical University, Nanjing, Jiangsu
bDepartment of Pathophysiology, Xuzhou Medical University, Xuzhou, China
Correspondence to Dr Ye-Bo Zhou, MD, PhD, Department of Physiology, Nanjing Medical University, 101 Longmian Road, Nanjing 211166, China. Tel: +86 25 86869351; fax: +86 25 86869351; e-mail: [email protected]
Abbreviations: AAR, adipose afferent reflex; AAV, adeno-associated virus; AAV-ADM, adeno-associated virus vectors encoding ADM; ABP, arterial blood pressure; ADM, adrenomedullin; BP, blood pressure; BW, body weight; CAP, capsaicin; CHF, chronic heart failure; CNS, central nervous system; CRLR, calcitonin receptor-like receptor; eGFP, enhanced green fluorescent protein; GABA, gamma-aminobutyric acid; HFD, high-fat diet; HW/BW, heart weight to body weight; iWAT, inguinal white adipose tissue; MAP, mean arterial pressure; NE, norepinephrine; nNOS, neuronal NO synthase; NO, nitric oxide; NOx, NO metabolites; OH, obesity-related hypertension; p-nNOSser-1417, nNOS phosphorylation at the amino acid residue Ser1417; PVN, paraventricular nucleus; RAMP2, receptor activity modifying protein 2; RAMP3, receptor activity modifying protein 3; RSNA, renal sympathetic nerve activity; SBP, systolic blood pressure; SNA, sympathetic nerve activity; SNP, sodium nitroprusside; T-nNOS, total nNOS; WAT, white adipose tissue
Received 12 January, 2022
Revised 19 August, 2022
Accepted 22 August, 2022
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.jhypertension.com).
