ORAL: CEREBROVASCULAR DISEASESS-06-2: HYPERTENSION AND DEMENTIA ∼LEARNING A LESSON FROM THE SPRINT∼Mogi, Masaki1 Author Information 1Department of Pharmacology, Ehime University Graduate School of Medicine, Japan Journal of Hypertension 41(Suppl 1):p e22, January 2023. | DOI: 10.1097/01.hjh.0000912908.77656.70 Free Metrics Abstract Midlife hypertension is generally known as a risk factor for dementia in the elderly, however, the effect of elderly hypertension on dementia and the beneficial roles of antihypertensive treatment for dementia prevention have not been well known. The Systolic Blood Pressure Intervention Trial (SPRINT) revealed that intensive antihypertensive treatment prevents fatal and nonfatal major cardiovascular events and death from any cause. SPRINT-Memory and Cognition in Decreased Hypertension (MIND) also demonstrated the beneficial roles of intensive blood pressure (BP) control in significantly reducing the risk of mild cognitive impairment. Post-hoc analysis of SPRINT tells us about the effects of the intensive blood pressure lowering treatment on cognitive function, blood flow, morphological change of the brain, etc. Thus, in this presentation, I will discuss the effect of intensive BP control on cognitive impairment with learning a lesson from the SPRINT. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.