POSITION PAPERSUpdate of the position paper on arterial hypertension and erectile dysfunctionViigimaa, Margusa,b; Vlachopoulos, Charalambosc; Doumas, Michaeld; Wolf, Jaceke; Imprialos, Konstantinosd; Terentes-Printzios, Dimitiosc; Ioakeimidis, Nikolaosc; Kotsar, Andresf; Kiitam, Urmoa,b; Stavropoulos, Konstantinosd; Narkiewicz, Krzysztofe; Manolis, Athanasiosg; Jelakovic, Bojan.h; Lovic, Dragani; Kreutz, Reinholdj; Tsioufis, Konstantinosc; Mancia, Giuseppek; for the European Society of Hypertension Working Group on Sexual DysfunctionAuthor Information aCentre of Cardiology, North Estonia Medical Centre bInstitute of Health Technologies, Tallinn University of Technology, Tallinn, Estonia c1st Cardiology Department, National and Kapodestrian University of Athens d2nd Propedeutic Department of Internal Medicine, Aristotle University, Thessaloniki, Greece eDepartment of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland fTartu University Hospital, Tartu, Estonia gCardiology Department, Asklepeion Hospital, Athens, Greece hDepartment of Nephrology, Hypertension, Dialysis and Transplantation, University of Zagreb, Croatia iClinic for Internal Disease Intermedica, Nis, Serbia jInstitut für Klinische Pharmakologie und Toxikologie, Charité - Universitätsmedizin Berlin, Germany kUniversity of Milano Bicocca, Milano, Italy Correspondence to Margus Viigimaa, MD, PhD, Centre of Cardiology, North Estonia Medical Centre, Tallinn, Estonia, Institute of Health Technologies, Tallinn University of Technology, Tallinn, Estonia. E-mail: [email protected] Abbreviations: ARBs, angiotensin receptor blockers, CAD, coronary artery disease; IIEF, International Index of Erectile Function; METs, metabolic equivalents of exercise; NO, nitric oxide; OSAS, obstructive sleep apnea syndrome; PDE-5, phosphodiesterase type 5; TRT, testosterone replacement therapy Received 23 June, 2019 Revised 10 January, 2020 Accepted 12 January, 2020 Journal of Hypertension: July 2020 - Volume 38 - Issue 7 - p 1220-1234 doi: 10.1097/HJH.0000000000002382 Buy Metrics Abstract Sexual health is an integral part of overall health, and an active and healthy sexual life is an essential aspect of a good life quality. Cardiovascular disease and sexual health share common risk factors (arterial hypertension, diabetes mellitus, dyslipidemia, obesity, and smoking) and common mediating mechanisms (endothelial dysfunction, subclinical inflammation, and atherosclerosis). This generated a shift of thinking about the pathophysiology and subsequently the management of sexual dysfunction. The introduction of phosphodiesterase type 5 inhibitors revolutionized the management of sexual dysfunction in men. This article will focus on erectile dysfunction and its association with arterial hypertension. This update of the position paper was created by the Working Group on Sexual Dysfunction and Arterial Hypertension of the European Society of Hypertension. This working group has been very active during the last years in promoting the familiarization of hypertension specialists and related physicians with erectile dysfunction, through numerous lectures in national and international meetings, a position paper, newsletters, guidelines, and a book specifically addressing erectile dysfunction in hypertensive patients. It was noted that erectile dysfunction precedes the development of coronary artery disease. The artery size hypothesis has been proposed as a potential explanation for this observation. This hypothesis seeks to explain the differing manifestation of the same vascular condition, based on the size of the vessels. Clinical presentations of the atherosclerotic and/or endothelium disease in the penile arteries might precede the corresponding manifestations from larger arteries. Treated hypertensive patients are more likely to have sexual dysfunction compared with untreated ones, suggesting a detrimental role of antihypertensive treatment on erectile function. The occurrence of erectile dysfunction seems to be related to undesirable effects of antihypertensive drugs on the penile tissue. Available information points toward divergent effects of antihypertensive drugs on erectile function, with diuretics and beta-blockers possessing the worst profile and angiotensin receptor blockers and nebivolol the best profile. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.