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Impact of simultaneous measurement of central blood pressure with the SphygmoCor Xcel during MRI acquisition to better estimate aortic distensibility

Soulat, Gillesa,b; Millasseau, Sandrinec; Stroer, Sébastiana,b; Tavolaro, Sébastiana,b; Kachenoura, Nadjiad; Khettab, Hakima,b; Boutouyrie, Pierrea,b; Laurent, Stéphanea,b; Mousseaux, Eliea,b

doi: 10.1097/HJH.0000000000002061
ORIGINAL PAPERS: Diagnostic aspects
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Objectives: Aortic distensibility estimation of local aortic stiffness is based on local aortic strains and central pulse pressure (cPP) measurements. Most MRI studies used either brachial PP (bPP) despite differences with cPP, or direct cPP estimates obtained after MRI examination, assuming no major pressure variations. We evaluated the feasibility of assessment of cPP with a specific device fitted with a 6 m long hose (study1) and looked at the influence of using such cPP within the magnet instead of bPP on aortic distensibility in a control population (study 2).

Methods: Brachial and central pressures values were recorded with the SphygmoCor XCEL system fitted with 2 and 6 m long tubing randomly assigned on arms. A 6 m long tubing was used in the second study to measure aortic distensibility with MRI. Aortic distensibility was calculated using either bPP (bAD) or cPP (cAD).

Results: Study1, performed on 38 patients (mean age: 43 ± 17 years), showed no statistical difference between bPP and cPP measured with 2 or 6 m long tubing (0.41 ± 4.45 and 0.78 ± 3.18 mmHg, respectively, both P = ns). In study 2, cAD provided statistically higher values than bAD (1.87 ± 1.43 10−3 · mmHg−1, P < 0.001) especially in younger individuals (3.28 ± 0.86 10−3 · mmHg−1). The correlation between age and aortic distensibility was stronger with cAD (r = −0.92; P < 0,001) than with bAD (r = −0.88; P < 0.001).

Conclusion: cPP can be estimated with reasonable accuracy during MRI acquisition using a 6 m long tube. Using either cPP or bPP greatly influences aortic distensibility values, especially in young individuals in whom an accurate detection of early or accelerated vascular aging can be of major importance.

aParis-Cardiovascular Research Center, INSERM UMR 970

bHôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Université Paris Descartes, Paris

cPulse Wave Consulting, Saint Leu La Foret

dSorbonne Universités, UPMC, INSERM 1146, CNRS 7371, Laboratoire d’Imagerie Biomédicale, Paris, France

Correspondence to Elie Mousseaux, MD, PhD, Cardiovascular Imaging Unit, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Université Paris Descartes, 20 rue Leblanc, 75015 Paris, France. Tel: +33 1 56 09 3709; e-mail: elie.mousseaux@aphp.fr

Abbreviations: Aix, augmentation index; bAD, aortic distensibility calculated with brachial pulse pressure; bBP, brachial blood pressure; bDBP, brachial DBP; bPP, brachial pulse pressure; bSBP, brachial SBP; cAD, aortic distensibility calculated with centrale pulse pressure; cBP, central blood pressure; cDBP, central DBP; cfPWV, carotid–femoral PWV; cPP, central pulse pressure; cSBP, central SBP; PWV, pulse wave velocity

Received 16 October, 2018

Revised 7 January, 2019

Accepted 10 January, 2019

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