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Large artery stiffness is associated with marinobufagenin in young adults

the African-PREDICT study

Strauss, Michéla; Smith, Waynea,b; Wei, Wenc; Bagrov, Alexei Y.c; Fedorova, Olga V.c; Schutte, Aletta E.a,b

doi: 10.1097/HJH.0000000000001866

Objectives: The cardiotonic steroid, marinobufagenin (MBG), has been shown to play a physiological natriuretic role in response to salt intake. However, recent studies in clinical and animal models demonstrated possible links between elevated levels of endogenous MBG and increased arterial stiffness. Large artery stiffness is a known predictor of future cardiovascular disease. We, therefore, investigated whether large artery stiffness relates to 24-h urinary MBG excretion in young apparently healthy black and white adults.

Methods: This study included data of 711 participants (black 51%, men 42%, mean age 24.8 ± 3.02 years). We measured the carotid–femoral pulse wave velocity (cfPWV), 24-h urinary MBG and sodium excretion.

Results: In single, partial and multivariable adjusted (Adj.) regression analyses, we found a persistent positive association between cfPWV and MBG excretion in women [Adj. R 2 = 0.23; standardized (std.) β = 0.15; P = 0.002], but not men (Adj. R 2 = 0.17; std. β = 0.06; P = 0.31). Multiple regression models were adjusted for ethnicity, age, waist-to-height ratio, mean arterial pressure, high-density lipoprotein cholesterol, C-reactive protein, γ-glutamyl transferase and glucose.

Conclusion: In conclusion, already at a young age heightened endogenous MBG levels may contribute to large artery stiffness in women via pressure-independent mechanisms, increasing their risk for future cardiovascular disease.

aHypertension in Africa Research Team (HART)

bMRC Research Unit: Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa

cNational Institute on Aging, NIH, Baltimore, Maryland, USA

Correspondence to Aletta E. Schutte, PhD, Hypertension in Africa Research Team (HART), North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. Tel: +27 18 299 2444; fax: +27 18 285 2432; e-mail:

Abbreviation: MBG, marinobufagenin

Received 27 February, 2018

Revised 4 June, 2018

Accepted 21 June, 2018

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