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A17512 The Features of Lipid spectre and plasma homocysteine content in patients with arterial hypertension associated with extra cranial arteries pathology

vamsi, Varahabhatla Sai Krishna Raghu1; Vinisha, Tekwani2; Virajitha, Maganty3; rao, Cherukuri Raja raghupathy2; reddy, Vadigala Bala Krishna3; Viktor, Buriak4

doi: 10.1097/01.hjh.0000548972.51492.38

Objectives: This study is devoted to the estimation of vascular remodelling processes in brachiocephalic arteries (BCA) and cerebral blood flow (CBF) indexes according to the plasma homocysteine (HC) content and lipid spectre components in patients with arterial hypertension (AH) associated with occlusive-stenotic lesions.

Methods: We examined 100 patients with AH at the age from 39 to 72 years. According to the results of duplex scanning of brachiocephalic arteries there were selected 50 patients with common carotid artery (CCA) intima-media thickness (IMT) 1,5 mm and above. The content of HC with immunoassay and plasma lipid spectre components by biochemical analysis were determined.

Results: It was found that patients with AH associated with BCA pathology are characterized by a significantly higher level of HC (2,08 times, P < 0,01), total cholesterol, low and very low density lipoproteins, triglycerides and index of atherogeny - by 26,02% (P < 0,001), 35,37% (P < 0,001), 32,84% (P < 0,01), 34,9% (P < 0,001) and 39,47% (P < 0,001) respectively. These findings are associated with a predominant increasing of CCA IMT by 60,58% (P < 0,05) as well as a decreasing of volume blood flow in both internal carotid and vertebral arteries and total volume velocity too by 14,11% (P < 0,05), 24,64% (P < 0,05) and 16,83% (P < 0,05) respectively.

Conclusion: Appearance of BCA pathology in patients with AH is associated with negative dynamics of HC plasma level, lipid spectre components, IMT and CBF as well.

1General medicine Zaporozhye state medical university Ukraine

2General medicine, Zaporozhye State Medical University, Ukraine

3General medicine, Zaporozhye State Medical University, Ukraine

4Associate Professor, Internal diseases-2, Zaporozhye State Medical University, Ukraine

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