Despite the traditional measurement of brachial pressure (BP), the central pressure detection could only be possible with invasive techniques, until recently modern non-invasive was introduced into the clinics. Compared with the general population, cardio-renal morbidity is much higher in patients with resistant hypertension (RH) describing (CBP) a future indicator of cardiovascular or target organ damage. We investigated the value of CBP and pulse wave velocity (PWV) in group of RH patients non-invasively.
Data from 80 patients with RH (resistance to 3 or more drugs, one is diuretic) without chronic kidney disease, at University hospital Merkur, Zagreb from the period of June 2017 to January 2018 were analysed. The pulse wave velocity (PWV), mean arterial pressure (MAP), vessels age (older than biological age), pulse pressure (PP), central blood pressure (CBP), brachial pressure (BP) were evaluated using the noninvasive Agedio B900 device (Germany).
The median age was 58.75 ± 15.3; 27 (35%) of patients were male (M), avg 53.9 y. BP and CBP were elevated in all RH patients 53-Female (F);27-M. The difference between median concentration of BP (145.9/90.52mmHg, F-146.4/89.5, M-145/92) and CBP (132.16/91.78mmHg, F-132/90, M-131/94) was statistically significant for systolic BP (p < 0.01). The mean value of the total measured PWV value was higher than reference for age in all RHp and was 8.84 m/s. The mean value of PP and MAP was higher than reference (60.11 and 123,87 mmHg). The difference between sex was statistically significant for PWV (M/F = 8.1/9.2m/s, p < 0.01). The difference between MAP (M/F = 125.83/123) and PP (M/F = 56/62mmHg) was not statistically significant (p > 0.01).
Further studies should address cuff method as a promising device in practice in high risk RH population
1General medicine Zaporozhye state medical university Ukraine
2Internal medicine, Emergency Medicine University Hospital Merkur, Zagreb School of Medicine Croatia
3Faculty of Medicine Zagreb school of medicine Croatia