Strong relation of Arterial hypertension (AH) H frequency, severity and complications rate with obesity was established but exact mechanisms and differences in clinical course are still under discussion. So, our task was to compare data of ambulatory blood pressure monitoring (ABPM), lipidogram values and adipokines levels in patients with normal body mass index and obesity suffering from AH.
65 patients with controlled arterial hypertension were investigated. Age median was 49,0 (35,0; 63,0). Average disease duration was 7,5 (2,0; 13,0) years. Females – 67,6 %, males - 32,4 %. All patients obtained standardised antihypertensive treatment that included ICE blockers or their combination with thiazide diuretics. ABPM was conducted within 24–26 hours. Total cholesterol level, LDL and HDL were estimated using certified biochemical analyser. Leptin and adiponectine leves were measured employing diagnostic kit from BenderMed-SystemsGmbH (Austria) by means of immune-enzyme analysis Platinum (ELISA)
Monophasic blood plessure curve type by ABPM was prevalent in patients with AH and obesity (“non-dipper”) (83,3 % against 48,6% with normal BMI). Atherogenic changes of lipid spectrum of blood were detected in 92% of obese patients with AH against 61,2% of those with optimal BMI. Dysadipokinaemia was maked in patients with obesity: significant increase of leptin 91.78 times) and decrease of adiponectin (1.46 times) were detected. dysadipokinaemia correlated with dyslipidaemia and BMI.
Dysadipokinaemia is significant in obese patients with AH and persists on the background of pro-and antiatherogenic lipids fraction. That may be important factor interlinking both conitions. Adipokines levels need further investigation as possible sensitive indices and predictors of disease outcome.