To identify predictors of AF progression in patients with hypertension.
The study involved 136 patients (mean age 56,2 ± 4,9 years) followed up prospectively from September 2010 till June 2016. Observations (mean duration of 60 ± 3 months) included regular telephone interviews every 3 months and annual general clinical examination with laboratory and instrumental evaluation. Arrhythmia progression from paroxysmal to permanent form was evaluated.
Cardiovascular complications and AF progression were documented in 63 (46%) patients during the observation period of 60 ± 3 months. According to the results of multifactorial analysis, independent predictors of progression from paroxysmal to permanent AF in hypertensives were left ventricular hypertrophy (OR 1.25, CI 1.03–1.52) and increased arterial stiffness (OR 2.3, CI 1.95–2.65). Pulse wave velocity more than 1106 cm/s in hypertensive patients with paroxysmal AF could predict progression to permanent arrhythmia in the next 5 years (sensitivity 66.6%, specificity 63.8%).
The multifactorial analysis revealed significant impact of left ventricular hypertrophy and increased arterial stiffness on the risk of atrial fibrillation progression from paroxysmal to permanent form. Pulse wave velocity can be considered as a predictor of this progression.
I.M. Sechenov First Moscow State Medical University, Moscow, RUSSIA