High blood pressure (BP) promotes the development of hypertensive target organ damage (TOD). As the BP goal of 130/80 mmHg is now under debated, whether the thresholds of 130/80 mmHg and 140/90 mmHg differs in the patterns of TOD remains unclear. This analysis is focusing on the relationships between different BP groups and TOD.
This analysis is nested in Northern Shanghai Study (NSS, Clinicaltrials.gov NCT02368938), participants prospectively recruited from June 2014 to June 2017 [n = 2098, 45.52% men, aged 71.3 ± 6.1 years]. Preclinical TODs including arterial stiffening, left ventricular hypertrophy, left ventricular diastolic dysfunction, micro-albuminuria, chronic kidney disease, carotid hypertrophy and lower-extremity atherosclerosis were assessed in all the participants. Other clinical information was obtained by standard questionaire. Participants were categorized into four groups according to BP (goup1: < 120/80, group2: < 130/80, group3: < 140/90 and group4: over 140/90). Hypertensive target organ damages among four groups were compared. We fitted logistic regression models to assess the odds of different BP groups, compared with optimal BP group (<120/80).
LVMI in group2 is significantly lower than group3 (p < 0.05). However, after stratified by gender, group2 and group3 showed no significant differences in LVMI. Group2 and group3 showed no significant differences in other TOD including E/ea, cf-PWV, IMT, ABI, eGFR and UACR. In multivariate logistic regression models, group2 and group3 showed no significant differences in odds risk of all the TOD, as compared with optimal BP group (<120/80 mmHg).
Compared with 140/90 mmHg, the BP goal of 130/80 mm Hg makes no difference in identifying hypertensive target organ damage.
1Department of Cardiology, Shanghai Tenth Peoples Hospital, Tongji University School of Medicine, Shanghai, China
2institute of clinical epidemiology and evidence-based medicine, tongji university, shanghai, shanghai, China
3Paris Descartes University; AP-HP; Diagnosis and Therapeutic Center, Hôtel-Dieu, Paris, France