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NEW BP GOAL OF 130/80 MMHG MAKES NO DIFFERENCE IN IDENTIFYING HYPERTENSIVE TARGET ORGAN DAMAGE: THE NORTHERN SHANGHAI STUDY

JI, H.1; Lu, Y.1; Xiong, J.1; Yu, S.1; Chi, C.1; Li, J.1; Teliewubai, J.2; Blacher, J.3; Zhang, Y.1; Xu, Y.1

doi: 10.1097/01.hjh.0000538984.94082.8d
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Objective: High blood pressure (BP) promotes the development of hypertensive target organ damage (TOD). As the BP goal of 130/80 mmHg is now under debated, whether the thresholds of 130/80 mmHg and 140/90 mmHg differs in the patterns of TOD remains unclear. This analysis is focusing on the relationships between different BP groups and TOD.

Design and method: This analysis is nested in Northern Shanghai Study (NSS, Clinicaltrials.gov NCT02368938), participants prospectively recruited from June 2014 to June 2017 [n = 2098, 45.52% men, aged 71.3 ± 6.1 years]. Preclinical TODs including arterial stiffening, left ventricular hypertrophy, left ventricular diastolic dysfunction, micro-albuminuria, chronic kidney disease, carotid hypertrophy and lower-extremity atherosclerosis were assessed in all the participants. Other clinical information was obtained by standard questionaire. Participants were categorized into four groups according to BP (goup1: < 120/80, group2: < 130/80, group3: < 140/90 and group4: over 140/90). Hypertensive target organ damages among four groups were compared. We fitted logistic regression models to assess the odds of different BP groups, compared with optimal BP group (<120/80).

Results: LVMI in group2 is significantly lower than group3 (p < 0.05). However, after stratified by gender, group2 and group3 showed no significant differences in LVMI. Group2 and group3 showed no significant differences in other TOD including E/ea, cf-PWV, IMT, ABI, eGFR and UACR. In multivariate logistic regression models, group2 and group3 showed no significant differences in odds risk of all the TOD, as compared with optimal BP group (<120/80 mmHg).

Conclusions: Compared with 140/90 mmHg, the BP goal of 130/80 mm Hg makes no difference in identifying hypertensive target organ damage.

1Department of Cardiology, Shanghai Tenth Peoples Hospital, Tongji University School of Medicine, Shanghai, China

2institute of clinical epidemiology and evidence-based medicine, tongji university, shanghai, shanghai, China

3Paris Descartes University; AP-HP; Diagnosis and Therapeutic Center, Hôtel-Dieu, Paris, France

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