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EARLY VASCULAR AGEING SYNDROM: FROM RISK FACTORS TO THE DISEASE

Kindaliova, V.1; Pronko, T.1; Drozd, Y.2; Zdanchuk, G.3

Journal of Hypertension: June 2018 - Volume 36 - Issue - p e34
doi: 10.1097/01.hjh.0000539046.45593.7e
POSTERS’ SESSION PS01: EPIDEMIOLOGY AND RISK FACTORS: PDF Only
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Objective: A clear correspondence of the age and state of the arteries is not always observed. The concept of early vascular aging syndrome acquires clinical significance. The aim of the study was to assess correlation between vascular stiffness, endothelial dysfunction, vascular age and biological age in healthy volunteers and patients with arterial hypertension (AH).

Design and method: Group I includes 63 healthy volunteers 24 M/39F, 33–55 years old, mean age 48.5 ± 7.6. Group II includes 135 patients with AH 64 M/71F, 30–89 years old, mean age 54.8 ± 9.1, duration of hypertension 8.6 ± 6.7 years. The following were measured: cardio-ankle vascular index (CAVI) and vascular age using VaSera VS-1500N (Fukuda Denshi, Japan); carotid femoral pulse wave velocity (PWV) and forearm blood flow (FBF) using Impecard (Belarus).

Results: CAVI in group I – 7.59 ± 0.86, in group II – 8.42 ± 1.31, P < 0.0001; FBF in group I – 9.9 ± 20.7%, in group II – −0.9 ± 26.2%, P < 0.001; PWV in group I – 6.5 ± 3.3 m/s, in group II – 12.3 ± 8.7 m/s, P < 0.0001. Vascular age in group I was 47.5 ± 10.4 years. Vascular age in group II was 58.3 ± 11.1 years, it is differ from biological age, P < 0.05. CAVI in group I correlated with age (Rs = 0.47, P < 0.0001), number of cigarettes (Rs = 0.27, P < 0.05), vascular age (Rs = 0.88, P < 0.0001) and SCORE rate (Rs = 0.56, P < 0.05). CAVI in group II correlated with age (Rs = 0.54, P < 0.0001), duration of AH (Rs = 0.26, P < 0.01), systolic blood pressure (SBP) (Rs = 0.32, P < 0.001), vascular age (Rs = 0.85, P < 0.0001). PWV in group II correlated with duration of AH (Rs = 0.36, P < 0.0001).

The multivariate analysis of variance in group I performed with vascular age as the dependent factor and CAVI (F = 63.9, P = 0.0001), η – 64.1%; SBP (F = 27.7, P = 0.048), η – 29.2%. The multivariate analysis of variance in group II performed with vascular age as the dependent factor and CAVI (F = 83.4, P = 0.0001), η – 63.5%; SBP (F = 5.1, P = 0.0003), η – 21.7%.

Conclusions: CAVI and vascular age increase in patients with AH. CAVI is more closely related to aging than PWV and FBF. Thus CAVI may be useful predictor of vascular ageing.

1Grodno State Medical University, Grodno, Belarus

2Grodno Regional Clinical Hospital of Medical Rehabilitation, Grodno, Belarus

3Grodno Regional Clinical Hospital, Grodno, Belarus

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