To clarify the association of triglyceride (TG), high- and low- density lipoprotein cholesterols (HDL-C and LDL-C), blood pressure, fasting plasma glucose (FPG), uric acid (UA), high sensitive C-reactive protein (hsCRP), and urine albumin-to-creatinine (UACR) with brachial ankle pulse wave velocity (baPWV), which has been reported as a potential surrogate marker of arterial stiffness, in the Japanese large cohort of adults.
Design and method:
A total of 2,645 participants including 1,205 men (61.1 ± 9.9 years) and 1,440 women (61.2 ± 9.4 years) were enrolled in the present cross-sectional study. Systolic and diastolic blood pressure (SBP, DBP) were measured to obtain pulse pressure (PP). baPWV was measured using automatic device (BP-203RPE II form PWV/ABI, Omron Colin, Tokyo). Stepwise multiple regression analyses were performed adjusted for age, BMI, current smoking status, exercise habit, habitual alcohol consumption, and medication for hypertension, diabetes mellitus and dyslipidemia, including all indices shown above.
Mean ± SD of baPWV, SBP, DBP, PP, TG, FPG, hsCRP and UA were 1569.6 ± 366.1 (cm/sec), 131.2 ± 17.1 (mmHg), 77.3 ± 10.0 (mmHg), 54.0 ± 12.2 (mmHg), 139.8 ± 113.5 (mg/dL), 100.3 ± 20.3 (mg/dL), 0.09 ± 0.29 (mg/dL) and 5.8 ± 1.8 (mg/dL), respectively, in men, and 1486.6 ± 357.5 (cm/sec), 125.4 ± 18.1 (mmHg), 72.9 ± 10.0 (mmHg), 52.5 ± 12.5 (mmHg), 107.4 ± 68.2 (mg/dL), 94.7 ± 16.5 (mg/dL), 0.06 ± 0.19 (mg/dL) and 4.3 ± 1.3 (mg/dL), respectively, in women. In men and women, PP and FPG were significantly associated with baPWV (P < 0.001). In men, hsCRP showed significant association (P = 0.002). In women, TG showed significant association (P < 0.001). Since habitual alcohol consumption showed significant association in men (P = 0.002), those with or without this habit were analyzed separately. In men who drink alcohol beverage daily, UA showed significant association with baPWV besides PP and FPG (P = 0.008), whereas in men without this habit, hsCRP showed significant association besides PP and FPG (P = 0.011).
These results suggest that PP and FPG may correlate with arterial stiffness in both sex, and there may be sex differences in the influence-factors of arterial stiffness.