aDepartment of Internal Medicine, School of Medicine, Keio University
bDivision of Mucosal Immunology, Department of Microbiology and Immunology
cInternational Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo
dDepartment of Polymer Chemistry, Graduate School of Engineering, Kyoto University
eJapan Science and Technology Agency, Exploratory Research for Advanced Technology, Katsura Int’tech Center, Kyoto
fBiochemicals Division, Yamasa Corporation, Chiba, Japan
Correspondence to Tatsuhiko Azegami, MD, PhD, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Tel: +81 3 5363 3796; fax: +81 3 3359 2745; e-mail: [email protected]
Abbreviations: Ang, angiotensin; AT1R, angiotensin II type 1 receptor; BSA, bovine serum albumin; cCHP, cationic cholesteryl-group-bearing pullulan; di-GMP, diguanylate monophosphate; DMEM, Dulbecco's Modified Eagle's medium; ERK, extracellular signal-regulated kinase; nanogel, nanometer-sized hydrogel; PBS, phosphate-buffered saline; PBST, phosphate-buffered saline containing the nonionic detergent Tween 20; PspA, pneumococcal surface protein A; SHR, spontaneously hypertensive rat; VSMC, vascular smooth muscle cell
Received 25 December, 2016
Revised 30 May, 2017
Accepted 17 July, 2017
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