aDobney Hypertension Centre, School of Medicine and Pharmacology - Royal Perth Hospital Unit, University of Western Australia, Crawley, Western Australia, Australia
cDepartment of Cardiology and Department of Nephrology, Royal Perth Hospital, Perth, Western Australia, Australia
Correspondence to Professor Markus P. Schlaich, Dobney Hypertension Centre, School of Medicine and Pharmacology- Royal Perth Hospital Unit, Level 3, Medical Research Foundation Building, Rear 50 Murray Street, Perth, WA 6000, Australia. Tel: +61 8 9224 0382; fax: +61 8 9224 0374; e-mail: [email protected]
Abbreviations: BSA, bovine serum albumin; DAPA, dapagliflozin; ERK1/2, extracellular signal regulated protein kinases 1/2; FCS, fetal calf serum; f.o.v, field of view; HFD, high-fat diet; HG-DMEM, high-glucose Dulbecco's Modified Eagle Medium; HK2, human kidney 2; IL, interleukin; MTS, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium; PVDF, polyvinylidene difluoride; SGLT2, sodium/glucose cotransporter-2; SNS, sympathetic nervous system; TNF, tumour necrosis factor
Received 6 April, 2017
Revised 29 April, 2017
Accepted 10 May, 2017
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