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[PP.03.04] VICTORIA STUDY

SCREENING FOR EARLY VASCULAR AGING BY ARTERIAL STIFFNESS AND CENTRAL HEMODYNAMICS PARAMETERS IN PHYSICIANS

Shavarova, E.1; Kazahmedov, E.1; Orlov, A.2; Kobalava, Zh.1

doi: 10.1097/01.hjh.0000523265.78065.22
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Objective: to analyzed parameters of central hemodynamics, arterial stiffness and vascular age, to compare passport and vascular ages in physician's population.

Design and method: Observational multicenter screening study of doctor's health assessment in 12 Russian cities. Demographics; smoking status; anamnesis of arterial hypertension with/without therapy, established CV, renal diseases, diabetes mellitus; cholesterol level were registered. Peripheral BP, central BP, pulse wave velocity (PWV), aortic and peripheral augmentation index (AI), reflected wave transit time (RWTT) were assessed by oscillometric device BPlab Vasotens Office (OOO “Petr Telegin”).

Results: 464 individuals were included (247 normotensives (mean age 44 yrs) and 237 with arterial hypertension (AH) (mean age 58 yrs)). Central BP, PWV, and AI were significantly higher in the hypertensive group comparing to normotensive group (134.1 vs 112.1 mm Hg for systolic BP, 83.1 vs 77.4 mm Hg for diastolic BP, 12.2 vs 10.9 m/sec for aortic PWV, -8.1 vs -29.3% for peripheral AI, and 22.3 vs 12.1% for aortic AI), RWTT was significantly lower in hypertensive patients (118.7 versus 132.9 ms). After adjusting for confounding factors significant intergroup difference was presented for central BP, RWTT, and peripheral AI. PWVao >10 m/s had 68% subjects without AH and 92% pts with AH, elevation of pulse pressure >60 mm Hg had 11% subjects without AH and 43% pts with AH. The most pts with AH (82%) and 31% of normotensives had increased vascular age comparing to passport one. The same passport and vascular age were observed in 10% pts with AH and 12% without it. Vascular age was lower than passport one in 55% of normotensives and 8% of hypertensive pts.

Conclusions: Prevalence of PWVao elevation is high in observed population and noninvasive cuff-based device could be implemented for every day practice for arterial stiffness and central hemodynamics evaluation. Early vascular aging was typical in hypertensive group. Vascular age evaluation could be useful instrument in treatment motivation improving strategy.

1RUDN University, Moscow, Russia

2National Research Nuclear University MEPhI, Moscow, Russia

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