ARTICLESVisit-to-visit SBP variability and cardiovascular disease in a multiethnic primary care setting 10-year retrospective cohort studyChia, Yook Chin; Ching, Siew Mooi; Lim, Hooi MinAuthor Information aDepartment of Primary Care Medicine, University of Malaya Primary Care Research Group (UMPCRG), Faculty of Medicine, University of Malaya, Kuala Lumpur bSunway Institute for Healthcare Development, Sunway University, Petaling Jaya cDepartment of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia dMalaysian Research Institute on Ageing, Universiti Putra Malaysia, Serdang, Malaysia Correspondence to Yook Chin Chia, Department of Primary Care Medicine, University of Malaya Primary Care Research Group (UMPCRG), Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Tel: +60 3 7949 2620; fax: +60 3 7957 7941; e-mail: [email protected] Abbreviations: α-blocker, alpha-blocker; β-blocker, beta-blocker; BPV, blood pressure variability; CCB, calcium channel blocker; CKD, chronic kidney disease; CV, cardiovascular event; DM, diabetes mellitus; eGFR, estimated glomerular filtration rate; RAS, renin–angiotensin system Received 25 August, 2016 Revised 23 January, 2017 Accepted 10 February, 2017 Journal of Hypertension: May 2017 - Volume 35 - Issue - p S50-S56 doi: 10.1097/HJH.0000000000001333 Buy Metrics Abstract Objectives: The current study aims to determine the relationship of long-term visit-to-visit variability of SBP to cardiovascular disease (CVD) in a multiethnic primary care setting. Method: This is a retrospective study of a cohort of 807 hypertensive patients over a period of 10 years. Three-monthly clinic blood pressure readings were used to derive blood pressure variability (BPV), and CVD events were captured from patient records. Results: Mean age at baseline was 57.2 ± 9.8 years with 63.3% being women. The BPV and mean SBP over 10 years were 14.7 ± 3.5 and 142 ± 8 mmHg, respectively. Prevalence of cardiovascular event was 13%. In multivariate logistic regression analysis, BPV was the predictor of CVD events, whereas the mean SBP was not independently associated with cardiovascular events in this population. Those with lower SBP and lower BPV had fewer cardiovascular events than those with the same low mean SBP but higher BPV (10.5 versus 12.8%). Similarly those with higher mean SBP but lower BPV also had fewer cardiovascular events than those with the same high mean and higher BPV (11.6 versus 16.7%). Other variables like being men, diabetes and Indian compared with Chinese are more likely to be associated with cardiovascular events. Conclusion: BPV is associated with an increase in CVD events even in those who have achieved lower mean SBP. Thus, we should prioritize not only control of SBP levels but also BPV to reduce CVD events further. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.