The aim of the study was to address the impact of hemorrhoid on the development of PAD with or without concomitant comorbidities.
Design and Method:
This retrospective cohort study used reimbursement claims data from the Longitudinal Health Insurance Database 2000 (LHID 2000) in Taiwan. Study subjects were composed of patients with hemorrhoids (International Classification of Diseases, 9th Revision, Clinical Modification [ICD-9-CM] code 455) (n = 37997), and a comparison cohort without hemorrhoids (n = 37997) from 2000 to 2010. Both cohorts were frequency matched by sex, age (every 5 years span) and index year in a 1:1 ratio. Cox proportional hazards regression was used to assess the hazard ratio (HR) of PAD associated with hemorrhoid.
The overall incidence rate of PAD were 3.59 per 1000 person-years in the hemorrhoid patients and 3.04 per 1000 person-years in the matched control patients with an adjusted hazard ratio (HR) of 1.16 (95% CI = 1.06–1.28; p < 0.001) during 12 years follow-up period.
Our finding suggested that patients with hemorrhoids are at an increased risk of PAD compared with those without hemorrhoids after adjusting for age, sex and comorbidities. Further studies are required to confirm our finding.