Cardio ankle vascular index (CAVI) represents arterial stiffness of the aorta, femoral artery and tibial artery. We investigated whether annual change of CAVI correlate to the onset of ischemic changes on electrocardiogram (IC).
Design and Method:
Subjects were 1,245 (male 48.0%) urban residents who participated in cardiovascular disease (CVD) screening in Japan during 2005- 2011. All subjects had normal ECG at first health check and had not received medical treatment for CVD risk factor during this study. Annual change of cardio-ankle vascular index (ΔCAVI) was obtained by cox hazard ratio from least-square method for three years by each year. Several atherosclerosis risk factors were also studied. IC was defined with Minnesota code.
IC occurred on the 60 people (male 25.0%). In first health check data, body mass index (BMI) and systolic blood pressure (sBP) were higher in IC group (group A) than normal ECG group (group B) in female, and regardless of the gender, but age, systolic blood pressure, diastolic blood pressure, triglyceride and CAVI were higher in group A than that of group B regardless of the gender (p < 0.05, respectively.). In male, Δsystolic blood pressure and ΔCAVI and age were selected as independent contributing factor for IC and ΔCAVI was much more significant than CAVI in first health check data. In female, only age was selected as an independent contributing factor for IC. Cox hazard ratio revealed that Δ body mass index correlate negative to ΔCAVI and Δ Blood sugar, ΔLDL-cholesterol, Δ γ-GTP and age correlate positive to ΔCAVI in male and female (p < 0.05 respectively). These results indicated that treatment for risk factors of metabolic syndrome and anti-aging could be decreasing ΔCAVI.
These results indicated that annual change of CAVI might be useful predicting factor for the onset of CVD in male.