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Association between cardiorespiratory fitness and submaximal systolic blood pressure among young adult men: a reversed J-curve pattern relationship

Prasad, Vivek K.a; Drenowatz, Clemensa; Hand, Gregory A.b; Lavie, Carl J.c; Sui, Xuemeia; Demello, Madisona; Blair, Steven N.a

doi: 10.1097/HJH.0000000000000715
ORIGINAL PAPERS: Exercise

Objectives: Exercise blood pressure is a marker of future cardiovascular morbidity and mortality among individuals with or without high resting BP or any other cardiovascular disease (CVD) signs and symptoms at present. The purpose of this study was to evaluate the association between SBP during submaximal exercise and cardiorespiratory fitness (CRF) among young men. Further, we investigated the trend displayed by submaximal SBP (SSBP) across different levels of CRF.

Methods: Graded exercise test (GXT) using a Modified Bruce protocol was performed on 204 men; SSBP was recorded at each stage of the protocol. Quintiles of CRF were established on the basis of peak oxygen consumption (VO2), with the first quintile (Q) being the lowest fit group and fifth Q the most fit.

Results: The mean VO2 peaks in Q 1 through 5 were 32.3, 39.1, 43.4, 48.1 and 55.5 ml/kg per min, respectively. In a model adjusted for age, race, body fat percentage, resting SBP, alcohol intake and smoking, the largest difference in SSBP was observed between men in Q 1 and 2, with 7.6 mmHg (P = 0.05), 9.4 mmHg (P = 0.02) and 9.5 mmHg (P = 0.04) lower SSBP at minutes 6, 8 and 10 of GXT, respectively. SSBP plateaus at Q 3, followed by an increase in the higher Qs, although still lower than Q1.

Conclusion: There was a reverse J-curve pattern relationship between SSBP and CRF, with the lowest SSBP among men with fair or good CRF and highest among those with poor CRF.

Video abstract: http://links.lww.com/HJH/A538

Supplemental Digital Content is available in the text

aDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina

bSchool of Public Health, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia, USA

cCardiac Rehabilitation and Prevention, Director, Stress Testing Laboratory, John Ochsner Heart and Vascular Institute, Ochsner Clinical School - The University of Queensland School of Medicine, New Orleans, Louisiana, USA

Correspondence to Vivek K. Prasad, Department of Exercise Science, Arnold School of Public Health, 921 Assembly Street, University of South Carolina, Columbia, SC-29201, USA. Tel: +1 8035538725; e-mail: prasadv@E-Mail.sc.edu

Abbreviations: BP, blood pressure; CHD, coronary heart disease; CRF, cardiorespiratory fitness; CVDs, cardiovascular diseases; DXA, dual X-ray absorptiometry; EDV, endothelium-dependent vasodilation; GXT, graded exercise test; LVH, left ventricular hypertrophy; SSBP, submaximal SBP; VO2, oxygen consumption

Received 17 February, 2015

Revised 1 July, 2015

Accepted 1 July, 2015

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.jhypertension.com).

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.