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Aortic stiffness is associated with elevated high-sensitivity cardiac troponin T concentrations at a chronic stage after ST-segment elevation myocardial infarction

Feistritzer, Hans-Josefa; Klug, Gerta; Reinstadler, Sebastian J.a; Mair, Johannesa; Seidner, Benjamina; Mayr, Agnesb; Franz, Wolfgang-Michaela; Metzler, Bernharda

doi: 10.1097/HJH.0000000000000644
ORIGINAL PAPERS: Heart
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Objectives: Aortic pulse wave velocity (PWV) – the proposed gold standard for the assessment of aortic stiffness – is a major determinant of left ventricular after-load and coronary perfusion. We aimed to investigate the association between aortic PWV and subclinical elevation of high-sensitivity cardiac troponin T (hs-TnT) concentrations at a chronic stage after acute ST-segment elevation myocardial infarction (STEMI).

Methods: Seventy-four patients with acute STEMI were included in this cross-sectional single-centre study at the University Hospital of Innsbruck. All patients underwent cardiac MRI for the assessment of left ventricular function, morphology, infarct size and aortic PWV 12 months after acute STEMI. Blood samples were drawn at 12 months by peripheral venipuncture. Levels of hs-TnT were measured by a commercially available immunoassay (Roche Diagnostics).

Results: hs-TnT levels (6.4 ng/l, inter-quartile range 5.0–8.6) were significantly associated with age (r = 0.417, P < 0.001), plasma creatinine levels (r = 0.257, P = 0.027), high-sensitivity C-reactive protein levels (r = 0.281, P = 0.015) and aortic PWV (r = 0.435, P < 0.001). Multiple linear regression analysis revealed aortic PWV (ß = 0.330, P = 0.025), apart from plasma creatinine concentrations (ß = 0.279, P = 0.010), to be independently associated with hs-TnT concentrations (model: R = 0.597, P < 0.001).

Conclusion: The present study showed an association of aortic stiffness and hs-TnT concentrations at a chronic stage after STEMI.

aUniversity Clinic of Internal Medicine III, Cardiology and Angiology

bUniversity Clinic of Radiology, Medical University of Innsbruck, Anichstrasse 35, Innsbruck, Austria

Correspondence to Bernhard Metzler, MD, MSc, University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria. Tel: +43 512 504 81315; fax: +43 512 504 22767; e-mail: Bernhard.Metzler@uki.at

Abbreviations: ACC, American College of Cardiology; AMI, acute myocardial infarction; CCS, Canadian Cardiovascular Society; CMR, cardiac magnetic resonance; ESC, European Society of Cardiology; hs-TnT, high-sensitivity cardiac troponin T; IQR, inter-quartile range; NT-proBNP, N-terminal pro-B-type natriuretic peptide; NYHA, New York Heart Association; p-PCI, primary percutaneous coronary intervention; PWV, pulse wave velocity; STEMI, ST-segment elevation myocardial infarction; trueFISP, true fast imaging with steady-state precession

Received 12 November, 2014

Revised 30 April, 2015

Accepted 30 April, 2015

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