Arterial stiffness may be a mechanism to explain the association between uric acid and cardiovascular disease. We aimed to analyse associations between serum uric acid and regional and local arterial stiffness, and assess potential differences related to sex and glucose metabolism status.
A cross-sectional study was performed in 614 adults [52.6% men; mean age 58.7 ± 8.5 years; 23.2% type 2 diabetes mellitus (by design)] from The Maastricht Study. Arterial stiffness was assessed by carotid–femoral pulse wave velocity (cfPWV), distensibility, and compliance coefficient of the carotid and femoral artery, and carotid artery Young's elastic modulus.
Higher uric acid (per SD of 74 μmol/l) was associated with greater stiffness indicated by a significantly higher cfPWV [β = 0.216 (95% confidence interval 0.061, 0.372); P = 0.006] and lower carotid distensibility coefficient [β = −0.633 (95% confidence interval −1.099, −0.166); P = 0.008] after adjustment for sex, age, and glucose metabolism status. Associations lost significance after adjusting for mean arterial pressure, BMI, waist, smoking status, heart rate, total : high-density lipoprotein cholesterol ratio, triglycerides, estimated glomerular filtration rate, use of lipid-lowering, antihypertensive, and diabetes medication, and use of secondary uricosurics. No associations were found between uric acid and carotid compliance coefficient, carotid Young's elastic modulus, or stiffness of the femoral artery. A significant interaction (P < 0.10) with glucose metabolism status was found for cfPWV. However, none of the stratified associations were significant. There was no interaction with sex.
Uric acid was not significantly associated with stiffness of the aorta, or the carotid or femoral artery among adults aged 40–75 years without and with type 2 diabetes mellitus.
aDepartment of Internal Medicine, Division of Rheumatology, Maastricht University Medical Centre
bCAPHRI School for Public Health and Primary Care, Maastricht University
cDepartment of Internal Medicine, Maastricht University Medical Centre
dCARIM School for Cardiovascular Diseases
eNUTRIM School for Nutrition, Toxicology and Metabolism
fDepartment of Social Medicine
gDepartment of Epidemiology, Maastricht University, Maastricht, the Netherlands
Correspondence to José M.A. Wijnands, MSc, Maastricht University Medical Centre, P.O. Box 5800, 6202 AZ Maastricht, the Netherlands.Tel: +31 43 3875026; fax: +31 43 3875006; e-mail: email@example.com
Abbreviations: ΔD, distension; baPWV, brachial–ankle pulse wave velocity; cfPWV, carotid–femoral pulse wave velocity; cIMT, carotid intima–media thickness; D, arterial diameter; HR, heart rate; MAP, mean arterial pressure; PP, pulse pressure; YEM, Young's elastic modulus
Received 22 April, 2014
Revised 5 March, 2015
Accepted 5 March, 2015
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.jhypertension.com).