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The importance of night-time systolic blood pressure in diabetic patients: Dublin Outcome Study

Draman, Mohd S.a; Dolan, Eamonc; van der Poel, Lelanec; Tun, Tommy Kyawb; McDermott, John H.b; Sreenan, Seamusb; O’Brien, Eoind

doi: 10.1097/HJH.0000000000000576
ORIGINAL PAPERS: BP measurement

Objective: Diabetic patients exhibit a higher cardiovascular risk compared to people without diabetes. The use of ambulatory blood pressure monitoring (ABPM) is gaining popularity in this population. Night-time SBP has consistently been shown to be a potent predictor of cardiovascular risk in the normal population. We studied the predictive value of night-time ABPM in a cohort of diabetic patients.

Research design and methods: At baseline, when not on antihypertensive medication, 11 291 patients (5326 men, mean age 54.6 years) underwent ABPM. Using a computerized national registry of death, mortality outcome was ascertained. Among 859 diabetic patients with a mean follow-up of 5.3 years, there were 74 deaths.

Results: Compared to people without diabetes, those with diabetes had daytime and night-time SBP of 146.4 vs. 145.1 (P = NS) and 131.2 vs. 126.4 mmHg (P < 0.0001), respectively. As a consequence, more diabetic patients had a non-dipping night-time SBP profile (47.4 vs. 35.5%; P = < 0.0001). In a Cox proportional-hazards model, night-time SBP was an independent predictor of cardiovascular mortality in diabetic patients after adjustment for sex, age, smoking history, previous cardiovascular events, BMI and daytime SBP. The resultant hazard ratio for a 10-mmHg increase in night-time SBP for total cardiovascular, stroke and cardiac mortality was 1.32 (1.12–1.69), 1.95 (1.18–3.20) and 1.24 (0.99–1.56), respectively.

Conclusion: Night-time SBP is a significant predictor of cardiovascular mortality in patients with diabetes.

aInstitute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, UK

bDepartment of Endocrinology and Diabetes Mellitus, Connolly Hospital, Blanchardstown, Dublin 15

cDepartment of Medicine for Elderly, Connolly Hospital, Blanchardstown, Dublin 15

dConway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland

Correspondence to Mohd S. Draman, Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Room 260 C2 Link Corridor, University Hospital of Wales, Heath Park, Cardiff CF14 4XN, UK. Tel: +44 2920748481; fax: +44 2920744671; e-mail: DramanYusofMS@cardiff.ac.uk

Abbreviations: ABPM, ambulatory blood pressure monitoring; CVD, cardiovascular disease; HbA1, glycated haemoglobin; NICE, National Institute for Health and Clinical Excellence

Received 9 July, 2014

Revised 20 February, 2015

Accepted 20 February, 2015

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.