Obesity is one of the risk factor of cardiovascular disease (CVD). Especially, it is important to diagnose metabolic syndrome (Mets) by waist circumference (WC) for prevention of CVD. On the other hand, blood pressure is associated with left ventricular mass (LVM) which independently predicts CVD. The aim of our study was to identify CVD and major organ dysfunction factors as predictors of LVM with thorough medical examinations in healthy subjects.
Design and method:
A total of 1056 participants without diabetes mellitus, systolic dysfunction, chronic kidney disease or other heart diseases underwent a thorough physical examination including transthoracic echocardiography. LVM index (LVMI) > = 51 g/m2.7 was regarded as the left ventricular hypertrophy (LVH). We performed single and multiple logistic regression analyses of LVMI and cardiovascular risk factors, including MetS factors and indicators of major organ dysfunction. Obesity subjects (WC >= 85 cm in male, and >= 90 cm in female) and non-obesity subjects were also separately analyzed.
One thousand and ten adults (Age 62.8 ± 12.8, male 621) were analyzed in this study, and LVH was observed in 20.7% of subjects (n = 228, male 167/621). In obesity subjects (n = 433), 33.0% (n = 143) of subjects showed LVH. LVH was correlated with age, systolic blood pressure (SBP), diastolic BP, estimated glomerular filtration rate, total bilirubin, fasting blood sugar, HbA1c, and WC. Multiple logistic regression analysis indicated that aging, high SBP (> = 130mmHg) and abnormal WC were the independent predictors of LVMI (odds ratio; 1.05, 1.99, 3.03, 95% confidential interval; 1.01–1.06, 1.42 – 2.79, 2.16 – 4.25, respectively, P < 0.01).
Moreover, the average of LVMI in obesity subjects was significantly higher in both male and female (47.7 ± 13.5, 47.9 ± 14.1 g/m2.7) than its in non-obesity subjects (41.1 ± 10.3, 37.8 ± 10.1 g/m2.7)
Systolic blood pressure and waist circumference were the independent risk factors for Left ventricular hypertrophy in healthy individuals, and therefore might be useful for predicting cardiovascular disease during routine physical checkups.