aAustralian School of Advanced Medicine, Macquarie University
bHeart Research Institute and University of Sydney, Newtown, Sydney, New South Wales, Australia
Correspondence to Professor Jacqueline K. Phillips, BVSc (Hons), PhD, Australian School of Advanced Medicine, Macquarie University, Sydney, NSW, 2109 Australia.Tel: +61 2 98502753; fax: +61 2 98123610; e-mail: [email protected]
Abbreviations: ACE, angiotensin-converting enzyme; AT1R, angiotensin II type 1 receptor; CKD, chronic kidney disease; HR, heart rate; LPK, Lewis polycystic kidney rat; lSNA, lumbar sympathetic nerve activity; MAP, mean arterial pressure; MAP50, mean arterial pressure at the mid-point of the curve; MAPsat, saturation mean arterial pressure at which there is no further change in SNA; MAPthr, threshold mean arterial pressure to trigger a change in SNA; N2, nitrogen; NTS, nucleus tractus solitarii; PP, pulse pressure; RAS, renin–angiotensin system; rSNA, renal sympathetic nerve activity; RVLM, rostral ventrolateral medulla; SNA, sympathetic nerve activity; SNP, sodium nitroprusside; sSNA, splanchnic sympathetic nerve activity
Received 30 July, 2014
Revised 9 January, 2015
Accepted 9 January, 2015
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