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Antihypertensive treatment is not a risk factor for major cardiovascular events in the Gubbio residential cohort study

Lanti, Mariapaolaa; Puddu, Paolo E.b; Vagnarelli, Oscar Terradurac; Laurenzi, Martinoc; Cirillo, Massimod; Mancini, Marioe; Zanchetti, Albertof; Menotti, Alessandroa

doi: 10.1097/HJH.0000000000000490
ORIGINAL PAPERS: Cardiovascular risk

Background and objectives: Demonstration of antihypertensive beneficial role in population settings is difficult. Relationships of antihypertensive treatment, blood pressure control, risk factors and cardiovascular outcomes were investigated in the Gubbio study.

Material and methods: Among 2248 cardiovascular disease-free men and women aged 35–74 years, individuals were classified as nonhypertensive, controlled hypertensive, uncontrolled hypertensive and untreated hypertensive based on cut-off limits of 140/90 mmHg for SBP/DBP and/or the use of antihypertensive drugs. End-point was the first major coronary, cerebrovascular or peripheral hard event [cardiovascular disease (CVD)] during a 15-year average. Univariate and multivariate analyses were run.

Results: Nonhypertensive individuals were about 10 years younger and had lower risk factor levels than the other categories. The relative risk (and 95% confidence interval) for CVD versus nonhypertension was 1.78 (1.02–3.10) for controlled hypertension, 3.76 (2.79–5.06) for uncontrolled hypertension and 3.30 (2.59–4.21) for untreated hypertension (UTH). After adjusting for covariates, such as sex, age, achieved blood pressure and other risk factors, the CVD risk of controlled hypertension was practically equal to that of nonhypertension, and remained unchanged even when blood pressure was excluded from the model (1.03, 0.58–1.82). The higher cardiovascular risk of uncontrolled hypertension and UTH was reduced after adjusting for covariates, but remained significantly higher than in nonhypertension, with no significant differences between uncontrolled hypertension and UTH.

Conclusions: A higher level of baseline risk is not due to treatment per se, the risk being similar in uncontrolled hypertension and UTH. Adjustment for risk factors reduces the risk only in controlled hypertension, suggesting that there may be structural alterations scarcely reversible by antihypertensive treatment.

aAssociazione per la Ricerca Cardiologica, Via Arco di Parma

bDepartment of Cardiovascular, Respiratory, Nephrological, Anesthesiological and Geriatric Sciences, Sapienza University of Rome, Viale del Policlinico, Rome

cCentre of Preventive Medicine, Gubbio

dDepartment of Medicine and Surgery, University of Salerno, Salerno

eDepartment of Clinical Medicine and Surgery, Federico II University, Naples

fIstituto Auxologico Italiano and University of Milan, Milan, Italy

Correspondence to Paolo E. Puddu, MD, PhD, FESC, FACC, Laboratory of Biotechnologies Applied to Cardiovascular Medicine, Department of Cardiovascular, Respiratory, Nephrological, Anesthesiological and Geriatric Sciences, Sapienza University of Rome, Viale del Policlinico, 155, Rome 00161, Italy. Tel: +39 06 49972659; fax: +39 06 4453891; e-mail:

Abbreviations: CI, confidence interval; CKD, chronic kidney disease; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LDL, low-density lipoprotein; UTH, untreated hypertension

Received 16 July, 2014

Revised 14 November, 2014

Accepted 14 November, 2014

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