REVIEWSAn update on the role of adipokines in arterial stiffness and hypertensionSabbatini, Andréa R.a; Fontana, Vanessaa; Laurent, Stephaneb; Moreno, HeitoraAuthor Information aDepartment of Pharmacology, Faculty of Medical Sciences University of Campinas – UNICAMP, Campinas, SP, Brazil bPharmacology Department and INSERM U970 Hospital Europeen Georges Pompidou, Assistance-Publique Hopitaux de Paris, Paris-Derscartes University, Paris, France Correspondence to Heitor Moreno, MD, PhD, Cardiovascular Pharmacology Laboratory, University of Campinas, FCM 10 Building, 1st Floor, Campinas – SP 13083-970, Brazil. Tel: +55 19 3521 9538; e-mail: email@example.com Abbreviations: baPWV, brachial to ankle pulse wave velocity; BP, blood pressure; cfPWV, carotid-femoral pulse wave velocity; CNS, central nervous system; CRHTN, controlled resistant hypertension; eNOS, endothelial nitric oxide synthase; ESC, European Society of Cardiology; ESH, European Society of Hypertension; ET-1, endothelin-1; hfPWV, heart to femoral pulse wave velocity; HMW, high molecular weight; hs-CRP, high-sensitive C-reactive protein; ICAM-1, intracellular adhesion molecule-1; IL-1, interleukin-1; IL-6, interleukin-6; IL-12, interleukin-12; LDL, low-density lipoprotein; MCP-1, monocyte chemoattractant protein-1; PP, pulse pressure; PWV, pulse wave velocity; RAAS, renin–angiotensin–aldosterone system; RHTN, resistant hypertension; TNF-α, tumour necrosis factor-alpha; UCRHTN, uncontrolled resistant hypertension; VCAM-1, vascular cell adhesion molecule 1; WAT, white adipose tissue Received 28 June, 2014 Revised 7 October, 2014 Accepted 8 October, 2014 Journal of Hypertension: March 2015 - Volume 33 - Issue 3 - p 435-444 doi: 10.1097/HJH.0000000000000444 Buy Metrics Abstract Adipokines are hormones produced by adipocytes and have been involved in multiple pathologic pathways, including inflammatory and cardiovascular complications in essential hypertension. Arterial stiffness is a frequent vascular complication that represents increased cardiovascular risk in hypertensive patients. Adipokines, such as adiponectin, leptin and resistin, might be implicated in hypertension, as well as in vascular alterations associated with this condition. Arterial stiffness has proven to be a predictor of cardiovascular events. Obesity and target-organ damage such as arterial stiffness are features associated with hypertension. This review aims to update the association between adipokines and arterial stiffness in essential and resistant hypertension (RHTN). Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.