ORIGINAL PAPERS: Central blood pressureSexual differences in central arterial wave reflection are evident in prepubescent childrenStoner, Leea; Faulkner, Jamesa; Westrupp, Nicoleb; Lambrick, Daniellec Author Information aSchool of Sport and Exercise, Massey University, Wellington bStarship Children's Hospital, Auckland District Health Board, Auckland cInstitute of Food, Nutrition and Human Health, Massey University, Wellington, New Zealand Correspondence to Lee Stoner, School of Sport and Exercise, Massey University, Private Bag 756, Wellington 6140, New Zealand. Tel: +64 4 801 5799 ext 62403; fax: +64 4 801 4994; e-mail: [email protected] Abbreviations: AP, augmentation pressure; [email protected], AP normalized to a HR of 75 bpm; cAIx, central augmentation index; [email protected], cAIx normalized to a HR of 75 bpm; cPP, central pulse pressure; cSBP, central SBP; pAIX, peripheral augmentation index; SEVR, Buckberg sub-endocardial variability ratio; Tr, time to reflection Received 15 February, 2014 Revised 26 August, 2014 Accepted 27 August, 2014 Journal of Hypertension: February 2015 - Volume 33 - Issue 2 - p 304-307 doi: 10.1097/HJH.0000000000000399 Buy Metrics Abstract Objective: The objective of this study was to examine the influence of sex on central arterial wave reflection in healthy prepubescent children matched for body size and cardiorespiratory fitness. Methods: Fifty-five healthy children (9.8 ± 1.0 years, 44% girls) were recruited. Cardiorespiratory fitness was assessed using a treadmill-based graded exercise test to volitional exhaustion. Pulse wave analysis was used to measure augmentation index (AIx) and central blood pressures. Results: The girls and boys were matched for age, body size and cardiorespiratory fitness. There were no significant differences between sexes for heart rate or central blood pressure parameters. Girls demonstrated a significantly greater AIx than the boys (8.9 ± 9.3 vs. 1.9 ± 10.8%, P = 0.015, d = 0.69). Conclusion: Sexual differences in central arterial wave reflection exist prepubescence, independent of stature or cardiorespiratory fitness. Further study is required to elucidate the mechanism(s) explaining this phenomenon and to determine the influence of wave reflections on left ventricular mass during childhood. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.