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Carotid–femoral pulse wave velocity in the elderly

Zhang, Yia; Agnoletti, Davideb; Xu, Yaweia; Wang, Ji-Guangc; Blacher, Jacquesb; Safar, Michel E.b

doi: 10.1097/HJH.0000000000000187

Predictive value of arterial stiffness in cardiovascular disease has been recognized for many decades. Carotid–femoral pulse wave velocity (cfPWV), as a noninvasive measurement, has been recommended as a gold standard of arterial stiffness, and we believe that this surrogate of arterial stiffness has been refined to the point that its utility in routine clinical practice need to be recommended. Considering the worldwide aging population and aging itself as a major cause of arterial stiffness, we would focus in this article, from a practical point of view, on cfPWV in the elderly, and review the current knowledge on the effect of arterial aging on cfPWV measurements, as well as the significance of its clinical application in the elderly.

aDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China

bParis Descartes University; AP-HP; Diagnosis and Therapeutic Center, Hôtel-Dieu, Paris, France

cCentre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

Correspondence to Michel E. Safar, MD, Centre de Diagnostic et de Thérapeutique, Hôtel-Dieu, 1, place du Parvis Notre-Dame, 75181 Paris Cedex 04, France.Tel: +33 1 42 34 80 25; fax: +33 1 42 34 86 32; e-mail:

Abbreviations: BP, blood pressure; BPA, blood pressure amplification; cfPWV, carotid–femoral pulse wave velocity; ESRD, end-stage renal disease; PPA, pulse pressure amplification

Received 10 November, 2013

Revised 25 February, 2014

Accepted 25 February, 2014

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