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CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension

Kassan, Modara; Wecker, Andreaa; Kadowitz, Philipb; Trebak, Mohamedc; Matrougui, Khalida

doi: 10.1097/HJH.0b013e328362feb7

Endothelial dysfunction plays a key role in the development and progression of cardiovascular disease. In patients with hypertension, endothelial dysfunction is characterized by a decrease of vasodilator factors release. Recent evidence highlights the involvement of regulatory T cell in the cardiovascular physiology and pathology. An increasing body of data suggest that an imbalance in the immune system triggers inflammation and compromises the cardiovascular homeostasis. In this mini-review, we will highlight the role of immune regulatory T cells in hypertension-induced vascular dysfunction.

aDepartment of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia

bDepartment of Pharmacology, Tulane University, New Orleans, Louisiana

cCollege of Nanoscale Science and Engineering, University at Albany, Albany, New York, USA

Correspondence to Khalid Matrougui, PhD, Department of Physiological Sciences, Eastern Virginia Medical School, 700W Olney Road, Norfolk, VA 23501, USA. Tel: +1 757 446 5278; e-mail:

Abbreviations: Ang II, angiotensin II; Tregs, natural regulatory T cells

Received 7 February, 2013

Revised 15 April, 2013

Accepted 6 May, 2013

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins