ORIGINAL PAPERS: Cerebrovascular diseaseInteractive relations of blood pressure and age to subclinical cerebrovascular diseaseWaldstein, Shari R.a,b,c; Wendell, Carrington R.a; Lefkowitz, David M.d; Siegel, Eliot L.d,e; Rosenberger, William F.f; Spencer, Robert J.a; Manukyan, Zorayrf; Katzel, Leslie I.b,c Author Information aDepartment of Psychology, University of Maryland, Baltimore County, Baltimore bDivision of Gerontology & Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore cGeriatric Research Education and Clinical Center, Baltimore Veterans Affairs Medical Center, Baltimore dDepartment of Diagnostic Radiology, University of Maryland School of Medicine, Baltimore eDepartment of Diagnostic Radiology, Baltimore Veterans Affairs Medical Center, Baltimore, Maryland fDepartment of Statistics, George Mason University, Fairfax, Virginia, USA Correspondence to Shari R. Waldstein, PhD, Department of Psychology, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA. Tel: +1 410 455 2374; fax: +1 410 455 1055; e-mail: [email protected] Abbreviations: BP, blood pressure; B-VAMC, Baltimore Veterans Affairs Medical Center; CHS, Cardiovascular Health Study; FLAIR, fluid attenuated inversion recovery; PP, pulse pressure; SBI, silent brain infarction; WMH, white matter hyperintensities Received 7 March, 2012 Revised 10 August, 2012 Accepted 14 August, 2012 Journal of Hypertension 30(12):p 2352-2356, December 2012. | DOI: 10.1097/HJH.0b013e3283595651 Buy Metrics Abstract Objective: To examine interactive relations of blood pressure (BP) and age to MRI indices of subclinical cerebrovascular disease in middle-aged to older adults. Methods: One hundred and thirteen stroke-free and dementia-free, community-dwelling adults (ages 54–81 years; 65% men; 91% white) engaged in (1) clinical assessment of resting SBP and DBP; (2) MRI rated for periventricular white matter hyperintensities (WMH) and deep WMH silent brain infarction (SBI) and brain atrophy (i.e. ventricular enlargement and sulcal widening ). Principal components analysis of the MRI ratings yielded a two-component solution – (1) periventricular and deep WMH SBI; and (2) ventricular enlargement, sulcal widening. Results: Relations of SBP, DBP and pulse pressure (PP) (and their interactions with age) to each MRI component were examined in multiple regression analyses adjusted for age, sex, fasting plasma glucose and cholesterol, and antihypertensives. For component 1, results indicated significant interactions of SBP and PP with age (P < 0.05); higher levels of SBP and PP were associated with greater white matter disease and brain infarction at younger ages (≤68 years). Significant interactions of SBP and DBP with age were also noted for component 2 (P < 0.05); higher levels of BP were associated with greater brain atrophy at younger ages (≤63 years). Conclusion: Higher BP and PP are associated with greater subclinical cerebrovascular disease most prominently in the ‘young old’. Appropriate management of hypertension and arterial stiffening may be critical to the preservation of brain structure with ageing. © 2012 Lippincott Williams & Wilkins, Inc.