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Anjum B; Verma, Narsingh; Tiwari, Sandeep; Singh, Ranjana; Mahdi, Abbas A; Singh, Ram B; Singh, Raj Km
Journal of Hypertension: September 2012
doi: 10.1097/01.hjh.0000419981.68773.30

Background and Objectives:

Shift work is known to cause circadian disruption of sleep leading to cardiovascular diseases (CVDs). We measured the circadian pattern of BP/HR in rotating night shift and day shift nursing professional's whether the changes in circadian pattern produced by rotating night shift are reversible.

Subjects and Methods:

We randomly recruited14 healthy nurses to perform day and night shift and another 14 nurses volunteer to perform day shift as controls (aged 20-40 years). Circadian pattern of BP/HR were evaluated by ambulatory BP monitors for (24 hours) in each subject in different shifts.


Night shift workers showed altered circadian pattern of double amplitude (predictable change) (SBP = 27.36 ± 18.83; DBP = 19.50 ± 12.78 of Night shift and SBP = 42.98 ± 20.75; DBP = 29.19 ± 13.48 of Day shift) when subjects went back to the day shift (SBP = p<0.04, DBP<0.02). A highly significant pattern of (SBP = 42.98 ± 20.75; DBP = 29.19 ± 13.48 of Day shift and SBP = 22.83 ± 10.99; DBP = 17.10 ± 6.83 of Controls) (SBP = p < 0.005, DBP = 0.006) of double amplitude was found between day shift and controls. Acrophase pattern (of individual subjects) was clinically significant in different shifts with controls. Significant changes were not found in MESOR values (p > 0.05).


Alterations in Acrophase were persistent during night as well as day shift due to incomplete recovery and ecphasia (odd timing of blood pressure) was very common among night shift workers caused by internal desynchrononization.

© 2012 Lippincott Williams & Wilkins, Inc.