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Arterial stiffness is increased in patients with inflammatory bowel disease

Zanoli, Lucaa,b; Cannavò, Mariaritaa; Rastelli, Stefaniaa; Di Pino, Luigia; Monte, Inesa; Di Gangi, Marcellaa; Boutouyrie, Pierreb; Inserra, Gaetanoa; Laurent, Stephaneb; Castellino, Pietroa

doi: 10.1097/HJH.0b013e3283568abd
ORIGINAL PAPERS: Oxidative stress and inflammation
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Background and aims: Recent studies have reported early atherosclerosis in patients with inflammatory bowel disease (IBD). In these patients, the chronic low-grade inflammation may predispose to vascular remodelling and arterial stiffening. We aimed at studying arterial stiffness in IBD patients.

Methods: Thirty-two IBD patients without cardiovascular risk factors and 32 matched controls were enrolled (age 19–49 years). SphygmoCor device (AtCor Medical, Sydney, Australia) was used to measure carotid–femoral and carotid–radial (muscular artery) pulse wave velocity (PWV), augmentation index and central blood pressure.

Results: Carotid–femoral PWV was higher in IBD patients than in controls (6.6 ± 1.4 vs. 6.0 ± 0.8 m/s, respectively, P < 0.05), as well as carotid–radial PWV (8.5 ± 1.2 vs. 7.2 ± 1.0 m/s, P < 0.001). Central pulse pressure was higher in IBD than in controls (32 ± 6 vs. 28 ± 7 mmHg, P < 0.05). Aging was an important determinant of carotid–femoral PWV in both groups and carotid–radial PWV only in IBD patients. In fully adjusted model performed in both groups of patients considered as a whole, age was positively associated with carotid–femoral PWV [R2 = 0.10; +0.05 m/s per 1 year of aging, 95% confidence interval (CI) 0.01–0.08 m/s, P < 0.05], as well as IBD (R2 = 0.10; +0.72 m/s if IBD present, 95% CI 0.19–1.26 m/s, P < 0.05). In IBD patients, carotid–radial PWV was positively associated with the disease duration (R2 = 0.20; +0.11 m/s per 1 year of aging, 95% CI 0.03–0.19 m/s, P < 0.05).

Conclusion: Arterial stiffness is increased in patients with IBD independently of conventional cardiovascular risk factors.

aDepartment of Internal Medicine, University of Catania, Catania, Italy

bDepartment of Pharmacology, Hôpital Européen Georges Pompidou, Assistance Publique, Hôpitaux de Paris, INSERM U970, Paris Descartes University, Paris, France

Correspondence to Luca Zanoli, MD, Department of Pharmacology, Hôpital Européen Georges Pompidou, Assistance Publique, Hôpitaux de Paris, 20, rue Leblanc, Paris 75015, France. Tel: +33 156093991; fax: +33 156093992; e-mail: zanoli.rastelli@gmail.com

Abbreviations: AIx75, Augmentation index corrected for a steady heart rate of 75 beats/min; CI, confidence interval; CRP, C-reactive protein; IBD, inflammatory bowel disease; PP, pulse pressure; PWV, pulse wave velocity

Received 25 October, 2011

Revised 6 February, 2012

Accepted 1 June, 2012

© 2012 Lippincott Williams & Wilkins, Inc.