REVIEWSHome versus ambulatory and office blood pressure in predicting target organ damage in hypertension a systematic review and meta-analysisBliziotis, Ioannis A.; Destounis, Antonis; Stergiou, George S. Author Information Hypertension Center, Third University Department of Medicine, Sotiria Hospital, Athens, Greece Correspondence to George S. Stergiou, MD, FRCP, Hypertension Center, Third University Department of Medicine, Sotiria Hospital, 152 Mesogion Avenue, Athens 11527, Greece.Tel: +30 2107763117; fax: +30 2107719981; e-mail: [email protected] Abbreviations: BP, blood pressure; cIMT, carotid intima–media thickness; GFR, glomerular filtration rate; LVM, left ventricular mass; LVMI, left ventricular mass index; PWV, pulse wave velocity; UAER, urinary albumin excretion ratio Received 7 October, 2011 Revised 5 February, 2012 Accepted 29 February, 2012 Journal of Hypertension: July 2012 - Volume 30 - Issue 7 - p 1289-1299 doi: 10.1097/HJH.0b013e3283531eaf Buy Metrics Abstract Objective: Studies have shown that ambulatory blood pressure (BP) is more closely related to preclinical target organ damage than office measurements. A review and meta-analysis of studies investigating the association of home BP measurements with target organ damage was performed. Methods: A PubMed and Cochrane Library search (1950–2011) revealed 23 studies reporting comparative data of home BP versus ambulatory and/or office measurements in terms of their association with several indices of target organ damage. Correlation coefficients were pooled by random-effects model meta-analysis. Results: Fourteen studies (n = 2485) assessing echocardiographic left ventricular mass index (LVMI) showed similar correlations with home (coefficients r = 0.46/0.28, systolic/diastolic) as with ambulatory BP (0.37/0.26, P = NS for difference versus home BP), and superior to office measurements (r = 0.23/0.19, P < 0.001/0.009 for difference versus home BP). Four methodologically heterogeneous studies assessing the glomerular filtration rate (n = 609) could not be pooled or lead to a concrete result. Four studies assessing carotid intima–media thickness (n = 1222), three assessing pulse wave velocity (n = 720) and two assessing urinary protein excretion (n = 156) showed no difference in pooled correlation coefficients with home versus office BP measurements. With all the measurement methods SBP was more closely associated with target organ damage than DBP. Conclusion: These data suggest that home BP is as good as ambulatory monitoring and superior to office measurements in regard to their association with preclinical organ damage assessed by echocardiographic LVMI. More research is required to evaluate the relationship of home BP with other indices of target organ damage. © 2012 Lippincott Williams & Wilkins, Inc.